Comparison of protective effect of two types of aerobic and intermittent training on breast cancer by TGFβ protein and Smad-3 gene and MMP2 in female mice
Hormozgan Medical Journal: May 01, 2017, 21 (1); e87270
May 15, 2017
Article Type: Research Article
February 08, 2017
May 15, 2017
M , Azarbayjani
M A , Homaee
H M. Comparison of protective effect of two types of aerobic and intermittent training on breast cancer by TGFβ protein and Smad-3 gene and MMP2 in female mice,
Hormozgan Med J.
Introduction: The aim of this study was to compare the protective effects of two types
of aerobic and intermittent training on breast cancer as a result of TGFβ protein, Smad-3,
and MMP2 gene in female mice.
Methods: In the experimental study, a total of 24 female BALB/c mice after
Tumorigenesis by MC4-L2 cell line in the three groups; Control, Aerobic, and
Intermittent training groups, and under standard conditions were studied. Aerobic
continuous training group performed 60 minutes of running on a treadmill with intensity
of 60-65% VO2max, 5 days a week and high-intensity intermittent program included six
bouts alternates (3 minutes and 20 seconds with intensity of 85–90%VO2max and a
minute of recovery with intense 30-35%VO2max between each alternate) for a period of
10 weeks. Data using one-way ANOVA and Tukey's test at a significance level of
P<0.05 were analyzed.
Results: High-intensity intermittent training significantly increased expression of Smad-3
(P<0.03), and protein TGF-β (P<0.000) and decreased the expression of MMP-2
(P<0.000) in tumor tissue than in the control group. Aerobic training also significantly
increased the expression of Smad-3 (P<0.03) and protein TGF-β (P<0.000) and decreased
the expression of MMP-2 (P<0.04) in tumor tissue than in the control group. No
significant differences in gene expression Smad-3 and MMP-2 between training groups was
observed (P<0.05), However, there was significant differences in the TGF-β protein
between High-intensity intermittent training and aerobic training groups (P<0.05).
Conclusion: It seems that high-intensity intermittent and aerobic continuous training can
possibly be effective interventions to reduce breast cancer progression and there is not
much difference between the effects of two types of training.
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