Protective effects of purslane seed (Portulaca Oleracea L.) on plasma levels of Cystatin C, Cathepsin S, and Creatinine in women with type 2 Diabetes


Parvin Farzanegi 1 , * , Maryam Shaerani Shaerani 2 , Mohammad Ali Azarbayjani 3


1 Associate Professor Department of Exercise Physiology, Islamic Azad University, Sari Branch, Sari, Iran.

2 MSc of Exercise Physiology 2 , Islamic Azad University, Sari Branch, Sari, Iran.

3 Professor Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran.


Hormozgan Medical Journal: 19 (1); e87366
Published Online: January 10, 2015
Article Type: Research Article
Received: May 16, 2013
Accepted: January 10, 2015




Introduction: Diabetes is a chronic metabolic disease which is associated with the
inflammation of cardiovascular system and kidney. Studies have shown that medicinal
plants could be effective in reducing inflammation; however, the effectiveness of purslane
(Portulaca oleracea) on inflammation is not well defined. Thus, this study attempted to
investigate the effect of Portulaca oleracea seed consumption on plasma levels of cystatin
C, cathepsin S, and creatinine in women with type 2 diabetes.
Methods: In this quasi-experimental study, 14 women with type 2 diabetes were
randomly divided into two equal groups of intervention and control (n=7). The subjects
received Portulaca oleracea seed 2.5 g at lunch and 5 g at dinner (totally 7.5 g) per day for
8 weeks. Blood was collected before and 48 hours after the last intervention. Data were
analyzed with paired and independent t-tests, and P<0.05 was considered significant.
Results: Levels of cystatin C, cathepsin S, creatinine, and lipid profile decreased
significantly in the intervention group after 8 weeks (P<0.05). There was also a
significant difference between the intervention and control groups in levels of cystatin C
and cathepsin S.
Conclusion: Changes in biochemical markers showed that Portulaca oleracea seed could
improve the levels of cardiovascular and kidney damage biomarkers and lipid profile in
diabetic patients. However, further research is needed for more accurate conclusions.


Cystatin C - Cathepsin S – Creatinine - Diabetes

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