Effect of zinc supplementation on preventing Diarrhea in children

AUTHORS

Mohammad Bagher Rahmati 1 , Marziyeh Barchinezhad Barchinezhad 2 , Mohammd Mehdi Houshmandi 3 , * , Homeyra Hamayeli Mehrabani 4 , Hamid Reza Mahboubi 5 , Saeed Hosseini 6

AUTHORS INFORMATION

1 Assistant Professor Department of Pediatric, Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Pediatrician, Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Pediatrician 2 , Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 PhD in Nutrition, Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

5 Internal Medicine Resident, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

6 Instructor Department of Epidemiology & Statisticsand, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

ARTICLE INFORMATION

Hormozgan Medical Journal: 19 (1); e87369
Published Online: April 17, 2013
Article Type: Research Article
Received: November 12, 2012
Accepted: April 17, 2013

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Abstract

Introduction: Diarrhea still remains a leading cause of mortality in developing countries.
Zinc has been reported to affect the treatment of acute gastroenteritis in children. This study
was aimed at evaluating the prophylactic effect of zinc on prevention of diarrhea in children.
Methods: This randomized clinical trial was performed on 100 children of 6-36 months
referring to Children Hospital outpatient clinic in Bandar Abbas who had no diarrhea during
the study and no underlying medical condition such as celiac and allergy to cow’s milk. The
subjects were randomly divided into two 50-member groups of supplementation who
received zinc sulfate for three months and control who received no drugs. All children were
followed up every 3 weeks for one year. Gastroenteritis, type of diarrhea, and the duration
of each episode were recorded. Data were analyzed with Chi-square and t-test.
Results: The mean age of the subjects was 21.5±7.9 months (ranged from 6 to 36
months); 61% of whom were male and 39% were female. There was no statistically
significant difference between the two groups in terms of baseline characteristics and history
of vaccination. The incidence of diarrhea, fever, and vomiting had no statistically significant
difference between both groups (P=0.83, P=0.88, P=0.53, respectively). No significant
difference existed between the groups in terms of the mean number of diarrheal episodes
(P=0.96) and the duration of diarrhea (P=0.09).
Conclusion: The use of zinc for three months as prophylaxis had no impact on reducing
the number and incidence of diarrhea in children aged between 6 and 36 months.

Keywords

Zinc – Diarrhea - Children

© 2015, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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