Effects of Colocynth (Citrullus colocynthis) Pulp on Serum Levels of Testosterone and Changes in Reproductive Organs in Streptozotocin-Induced Diabetic Rats

AUTHORS

Fereshteh Ostovan 1 , Ali Gol 2 , *

1 Instructor Department of Biology, Payame Noor University, Iranshahr, Iran.

2 Assistant Professor Department of Biology, Shahid Bahonar University, Kerman, Iran.

How to Cite: Ostovan F , Gol A . Effects of Colocynth (Citrullus colocynthis) Pulp on Serum Levels of Testosterone and Changes in Reproductive Organs in Streptozotocin-Induced Diabetic Rats, Hormozgan Med J. 2015 ; 19(2):e87440.

ARTICLE INFORMATION

Hormozgan Medical Journal: 19 (2); e87440
Published Online: March 12, 2013
Article Type: Research Article
Received: March 03, 2012
Accepted: March 12, 2013

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Abstract

Introduction: Investigating the effects of colocynth pulp on levels of testosterone and
changes in the reproductive system organs in streptozotocin-induced diabetic rats.
Methods: In this study, 32 Wistar rats were divided into four groups of normal (N),
normal+colocynth pulp (N+C), diabetic control (D), and diabetic+colocynth pulp
(D+C). Groups N and D received orally 2 mL normal saline for two weeks, and groups
N+C and D+C received orally 10 mg/kg colocynth pulp for two weeks. Diabetes was
induced in rats through intraperitoneal injection of 65 mg/kg streptozotocin (STZ).
Results: Group D showed a significant increase in glucose levels compared with Group
N (P<0.0001), and testosterone levels, body weight, and reproductive organs weight
ratio of group D decreased significantly compared with Group N (P<0.0001). In
addition, a significant reduction in glucose level (P<0.01) and a significant increase in
testosterone level and reproductive organs weight ratio (P<0.01) were observed in Group
D+C in comparison to Group D.
Conclusion: This study showed that consumption of 10 mg/kg colocynth for two weeks
relatively improved glucose and testosterone levels as well as reproductive system damage
in streptozotocin-induced diabetes in rats.

Keywords

Diabetes – Streptozotocin – Testosterone

© 2015, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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