Analyzing immunity against hepatitis A in 6-11 years old children in Kerman county

AUTHORS

Abbas Jahanara 1 , * , Ali Hosseininasab 2 , Ali Mohammad Arabzadeh 3 , Zahra Iranmanesh 4 , Azam Dehghani 5 , Najmeh Nikkpour 6

1 Resident of Pediatrics, Tropical Disease Research Center, Kerman University of Medical Scineces , Kerman, Iran.

2 Assistant Professor Department of Pediatrics, Tropical Disease Research Center, Kerman University of Medical Scineces , Kerman, Iran.

3 Associate Professor Department of Virology, Clinical Research Database, Kerman University of Medical Scineces, Kerman, Iran.

4 MSc of Microbiology, Clinical Research Database, Kerman University of Medical Scineces, Kerman, Iran.

5 MSc of Biostatistics, Clinical Research Database, Kerman University of Medical Scineces, Kerman, Iran.

6 BSc of Microbiology, Kerman University of Medical Scineces, Kerman, Iran.

How to Cite: Jahanara A, Hosseininasab A , Arabzadeh A M , Iranmanesh Z , Dehghani A , et al. Analyzing immunity against hepatitis A in 6-11 years old children in Kerman county, Hormozgan Med J. 2015 ; 19(3):e87462.

ARTICLE INFORMATION

Hormozgan Medical Journal: 19 (3); e87462
Published Online: June 11, 2013
Article Type: Research Article
Received: December 24, 2012
Accepted: June 11, 2013

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Abstract

Introduction: Hepatitis A is caused by a virus with a similar name. As a very
contagious disease, Hepatitis A is one of the most prevalent infant infections across the
developing countries. People who have been vaccinated and also those who caught this
disease already are immune against hepatitis A. Since it was not possible and cost effective
to analyze the immunity level of all asymptomatic children, in this study, the immunity
level of some children against this virus was measured in order to estimate their immunity
potential against this infection.
Methods: A total of 400 6-11 years old children in Kerman County, who have referred to
the Be'sat Specialized Clinic and infants emergency care ward of Afzalipour Hospital and
their blood have been collected for any reason except diagnosing hepatitis, were studied.
Children with chronic liver, blood, immunity system deficiency and malignity were
excluded from the study. Using ELISA technique and Dia-pro Milano Italy, made by Italy
(with a sensitivity of 100% and specialty of 99.6%), their serum was analyzed in terms of
anti-hepatitis data were analyzed using SPSS 16.
Results: 42.8% of children were immune against hepatitis A. 55% and 45% of children
referred to the mentioned medical centers were girl and boy, respectively. 59.1% of boys
and 40.9% of girls were immune, but there was not any significant difference between
them. There was a direct relationship between immunity and children's age, as with
increasing their age as large as 1 year their immunity level against hepatitis A is increased
as large as 0.75%. There was not found any relationship between the immunity level and
other demographic properties.
Conclusion: Most of 6-11 children are immune against hepatitis A because of their
asymptomatic disease.

Keywords

Hepatitis A – Antibody – Immunity - Children

© 2015, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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