The relationship between circulating levels of IL-18 and leptin, HsCRP, blood pressure and cardiorespiratory function in obese and lean men


Fatah Moradi 1 , *


1 Deprtment of Physical Education and Sport Sciences , Saghez Branch , Islamic Azad University , Saghez, Iran.


Hormozgan Medical Journal: 20 (4); e87467
Published Online: February 08, 2015
Article Type: Research Article
Received: July 21, 2014
Accepted: February 08, 2015




Introduction: Interleukin-18 (IL-18) is a proinflammatory cytokine that is produced in adipose tissue and skeletal muscle. The circulating levels of IL-18 increases in obesity and some metabolic and cardiorespiratory diseases. The aim of the present study is to investigate the relationship between circulating levels of IL-18 and leptin, high-sensitivity C-reactive protein (HsCRP), blood pressure and cardiovascular function in obese and lean men.

Methods: In a descriptive-analytical study, 19 obese men (Body Mass Index (BMI)≥30 kg/m2) and 19 lean men (BMI≤18) were selected as subjects. After 12 hours of fasting, blood samples were collected and general characteristics of the subjects were measured. The Pearson’s correlation coefficient at a significance level of P<0.01 was used to analyze the collected data.

Results: Serum IL-18 levels in obese men were directly correlated with BMI and body fat percentage (BFP), but no significant correlation was observed in lean men. IL-18 in obese and lean men was directly correlated with leptin and HsCRP. But, it was inversely correlated with cardiorespiratory function (VO2max). IL-18 levels in obese men were directly correlated with systolic blood pressure (SBP), but no significant correlation was found between IL-18 levels and diastolic blood pressure (DBP). No significant correlation was observed between IL-18 levels and SBP and DBP in lean men.

Conclusion: It seems that changes in anthropometric characteristics, blood pressure, cardiorespiratory function and hormones such as leptin and HsCRP can be effective in IL-18 changes. These findings reveal the role of IL-18 in some inflammatory, metabolic (including diabetes and metabolic syndrome) and cardiovascular (hypertension pressure and atherosclerosis) disorders, especially in obese patients.


Interleukin-18 Leptin C - Reactive Protein (CRP) Blood Pressure Obese

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