Effect of 12 weeks aerobic exercise on coronary heart diseases' markers of inflammation in middle-aged women


Maryam Bargharar 1 , Ali Khazani 2 , * , Narges Zeyaie 3 , Ayoub Hashemi 1 , Ebrahim Falah 4


1 MSc of Exercise Physiology, Islamic Azad University, Qeshm Branch, Qeshm, Iran.

2 Assistant Professor Department of Exercise Physiology, Islamic Azad University, Ardebil Branch, Ardebil, Iran.

3 MSc of Exercise Physiology, Islamic Azad University, Tehran Branch, Tehran, Iran.

4 MSc of Exercise Physiology, Tarbiat Modares University, Tehran, Iran.


Hormozgan Medical Journal: 19 (3); e87473
Published Online: October 20, 2013
Article Type: Research Article
Received: July 01, 2013
Accepted: October 20, 2013




Introduction: This study aims at analyzing the effect of 12 weeks physical exercise (30
minutes for three days a week: 70-85% of the maximum heart rate) on variations of
inflammation markers in middle-aged women's Coronary Heart diseases (CHDs).
Methods: In this study a total of 40 subjects including 40-55 years old women were
selected purposively and were divided into two experimental and control groups. The
experimental group members were asked to follow a certain physical exercise program
including 12 weeks physical exercise (30 minutes, three days a week with 70-85% of
maximum heart rate using a treadmill); whereas subjects in the control group were asked
to follow their normal lifestyle and do not change their activities and food habits. Levels
of factors that can affect coronary heart risks including fibrinogen, C-reactive protein
(CRP), and white blood cells (WBCs) were measured before and after exercises.
Independent and paired t-tests were used to analyze data.
Results: The results of this study indicated a significant decrease in fibrinogen, CRP, and
WBC levels after 12 weeks physical exercise in the experimental group (P≤0.05);
whereas no significant change was seen in the control group (P>0.05).
Conclusion: Regarding the results of this study we can conclude that performing
physical exercise (30 minutes, three days a week with 70-85% of maximum heart rate)
can play an effective role in reducing risk factors of coronary heart disease (CHD) and
hence in preventing coronary heart disease in 40-55 years old women with the similar
properties of patients examined in this study.


Risk Factors – Fibrinogen – C-Reactive Protein (CRP)

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