The frequency of interleukin-10 (IL-10) polymorphisms in patients with peptic ulcer and chronic gastritis

AUTHORS

Meysam Rezaeishahmirzadi 1 , Neda MotamediRad 2 , SeyedHamid Moosavy 3 , Mohammad Shekari 4 , *

1 eprtment of Medical Ge netics , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 eprtment of Medical Ge netics , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Department of Internal Medicine , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 Deprtment of Genetics , Molecular Medicine Research Center , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Rezaeishahmirzadi M , MotamediRad N , Moosavy S , Shekari M. The frequency of interleukin-10 (IL-10) polymorphisms in patients with peptic ulcer and chronic gastritis, Hormozgan Med J. 2016 ; 20(4):e87476.

ARTICLE INFORMATION

Hormozgan Medical Journal: 20 (4); e87476
Published Online: March 08, 2016
Article Type: Research Article
Received: June 09, 2014
Accepted: March 08, 2016

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Abstract

Introduction: Peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. It has been shown that Helicobacter pylori infection is related with inflammatory responses of gastric mucosa. However, some patients remain asymptomatic. Sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. The aim of this study is to investigate the genetic polymorphisms of inflammatory cytokine IL-10 and its relationship with peptic ulcer and gastric inflammation.

Methods: In this study, 107 people with symptoms of stomach pain and indigestion referred to a doctor with an indication for endoscopy were selected as the patient group. 107 healthy people without complications such as stomach pain and indigestion were selected as the control group. IL-10-592A/C polymorphism was examined by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).

Results: No significant difference was found between the patients with peptic ulcer and chronic inflammation and healthy people in the control group in terms of the C allele in the IL-10 gene (P=0.99; 0.48-1.80, CI 95%, OR 0.93, and P=0.26; 0.57-1.13, CI 95%, OR 0.81, respectively).

Conclusion: The results showed no significant correlation between the inflammatory cytokine IL-10 gene polymorphisms and peptic ulcer disease and chronic inflammation.

Keywords

Polymorphism Interleukin-10 Peptic Ulcer Chronic Gastritis

© 2016, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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