Effect of Angipars on Neuropathic Pain in Streptozotocin-Induced Diabetic Rats

AUTHORS

Naser Zangiabadi 1 , Mandana Jafari 2 , * , Mohammad Shaabani 3

1 Assistant Professor Department of Neurology, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.

2 MSc Student of Biology, Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran.

3 Assistant Professor Department of Neurophysiology, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.

How to Cite: Zangiabadi N, Jafari M, Shaabani M. Effect of Angipars on Neuropathic Pain in Streptozotocin-Induced Diabetic Rats, Hormozgan Med J. 2015 ; 19(4):e87557.

ARTICLE INFORMATION

Hormozgan Medical Journal: 19 (4); e87557
Published Online: June 09, 2014
Article Type: Research Article
Received: December 23, 2013
Accepted: June 09, 2014

Crossmark

CHEKING

READ FULL TEXT
Abstract

Introduction: Diabetes is the most common cause of peripheral nerve involvement.
Evaluating the effect of antioxidants on diabetic neuropathic pain is important. This study
aimed at evaluating the effects of Angipars medicine in the treatment of neuropathic
hyperalgesia in single dose streptozotocin-induced diabetic rats.
Methods: The study was performed on 50 Spraque dawley rats of 250-300 grams weight.
The rats were divided into four groups of control, sham, Angipars-receiving diabetic, and
vehicle-receiving diabetic, with at least 8 rats in each group. Diabetes was induced by
intraperitoneal injection of 45 mg/kg streptozotocin dissolved in a 0.05 M citrate buffer.
After confirming the diabetes, the diabetic rats received (5, 10, 20 mg/kg, intraperitoneal)
Angipars and vehicle for 2 weeks. At the end of the eighth week, the control and treated rats
were examined through the hot plate and tail flick tests. ANOVA was used to evaluate the
statistical difference and pvalue<0.05 was considered as significant.
Results: At the end of the eighth week, the response time to thermal hyperalgesia
decreased in the vehicle and sham groups compared with the control group. Angipars at
doses of 5 and 10 mg increased the response time to thermal hyperalgesia compared to the
vehicle and sham groups in hot plate test. In the tail flick test, 10mg Angipars increased the
response time to pain similar to the control group.
Conclusion: This study showed that, as an antioxidant, Angipars is capable of reducing
neuropathic hyperalgesia in animals with diabetes.

Keywords

Diabetic Neuropathies – Rats – Pain

© 2015, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

References

  • 1.

    Refrences are included in the PDF.

  • COMMENTS

    LEAVE A COMMENT HERE: