Comparison of effect of botulinum toxin with clopidogrel and concomitant prescription of them in the survival of random skin flap in rats

AUTHORS

Ferdos Moznebi 1 , Ghasemali Khorasani 2 , * , Seyed Abouzar Hoseini 3 , Kourosh Ghanbarzadeh 4 , Massoud Amanlou 5 , Batool Ghorbani Yekta 6

1 Assistant Professor Department of Surgery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Associate Professor Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.

3 Pathologist, Iran University of Medical Sciences, Tehran, Iran.

4 Assiatant Professor Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.

5 Professoe Department of Farmacy, Tehran University of Medical Sciences, Tehran, Iran.

6 Associate Professor Department of Internal Medicine, Neuroscince Research Center, Azad University, Tehran Branch, Tehran, Iran.

How to Cite: Moznebi F , Khorasani G , Hoseini S A , Ghanbarzadeh K, Amanlou M , et al. Comparison of effect of botulinum toxin with clopidogrel and concomitant prescription of them in the survival of random skin flap in rats, Hormozgan Med J. 2016 ; 19(6):e87648.

ARTICLE INFORMATION

Hormozgan Medical Journal: 19 (6); e87648
Published Online: September 16, 2014
Article Type: Research Article
Received: August 06, 2014
Accepted: September 16, 2014

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Abstract

Introduction: In this study, the effect of botulinum toxin A and clopidogrel and
concomitant administration of them in the survival of random skin flap in rat model were
studied.
Methods: First in all rats, flaps of 3×10 cm was created, the first group was the control
group, in the second group immediately after surgery, botulinum toxin with dose of
(international unit) 1.5 IU for was injected as intradermal. In the third group, immediately
after surgery, clopidogrel powder that was previously dissolved in the solution of sodium
chloride, orally using OGT (Orogastric Tube) and with a dose of 25 mg/Kg was fed to
animal. In the fourth group, after surgery, botulinum toxin like the second group and
Plavix combination like the third group with the same dose was prescribed. After 7 days,
level and flap cutting was measured and calculated by morphology and pathology.
Results: The mean of necrosis in control group was 21±2, in botulinum toxin A was
9.3±0.8, in clopidogrel group was 14±1.7 and in clopidogrel+botulinum toxin A was
12.6±1.5 percent. The difference was statistically significant between groups (P<0.0001).
Conclusion: The finding of our study showed that injection of botulinum toxin A
compared to control group and compared to clopidogrel group and combination of
clopidogrel with botulinum toxin A show greater effect in the survival of flap and
reducing distal necrosis.

Keywords

Flap Necrosis Botulinum Toxins Clopidogrel

© 2016, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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