Diagnostic reliability check of red cell indices in differentiating Iron Deficiency Anemia (IDA) from Beta Thalassemia Minor (BTT)

AUTHORS

mostafa ravanbakhsh 1 , * , Seyed Abdollah Mousavi 2 , Shahram Zare 3

1 Resident of Department of Pathology , Hormozgan University of Medical Sciences, Bandar Abbas, Iran

2 Assistant Professor Department of Pathology , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Professor Department of Community Midicine , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: ravanbakhsh M , Mousavi S A, Zare S . Diagnostic reliability check of red cell indices in differentiating Iron Deficiency Anemia (IDA) from Beta Thalassemia Minor (BTT), Hormozgan Med J. 2016 ; 20(3):e87668.

ARTICLE INFORMATION

Hormozgan Medical Journal: 20 (3); e87668
Published Online: January 04, 2016
Article Type: Research Article
Received: September 05, 2015
Accepted: January 04, 2016

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Abstract

Introduction: Iron deficiency anemia and beta-thalassemia trait are the two most common causes of hypochromic microcytic anemia. There are some discriminating functions (DFs) formula to differentiate these two conditions based on RBC's indices which would be compared the validity of the 14 various indices in this study.

Methods: A total of 227 patients from 21st March to 21st June 2014 were studied by calculating 14 DFs i.e. Keikhaei (KI), RDWI, Green & King (G & KI), England & Fraser (E & FI), Mentzer (MI), Shine & Lal (S & LI), Telmissani (TI), Ricerca (RI), Ehsani (EI), Keli (RBC) and 4 new indices (F1, F2, F3 & F4). The study included 105 iron deficient patient and 122 beta-thalassemia trait cases (HbA2>3.5 & HbA2<8%). The number of correctly diagnosed cases were determined and sensitivity, specificity, positive and negative predictive value and Youden index of each discrimination index were calculated.

Results: None of the indices showed 100% sensitivity and specificity. G & KI, KI, RDWI, E & FI, F3, EI and MI showed the highest value in differentiating IDA from BTT. The lowest value was belong to S & LI, F4 and F2 indices.

Conclusion: Based on Youden index (YI), the value of discrimination function indices from highest to lowest was as follow: G & KI> KI> RDWI> E & FI> F3> EI> MI> RBC> F1> RI> F2> F4> S & LI.

Keywords

Anemia Hypochromic Microcytic Iron Deficiency Anemia Beta-Thalassemia Trait

© 2016, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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