Responses of cytokines to influenza vaccination in elite boy gymnasts

AUTHORS

Parvin Farzanegi 1 , * , Mohammad Ali Azarbayjani 2 , Mohammad Javad Rasaee 3 , SR Stannard SR 4

AUTHORS INFORMATION

1 Associate Professor Department of Exercise Physiology , Islamic Azad University, Sari Branch, Sari, Iran

2 Professor Department of Exercise Physiology , Islamic Azad University, Central Tehran Branch, Tehran, Iran

3 . Professor Department of Clinical Biochemistry , Tarbiat Modares University, Tehran, Iran.

4 Professor School of Sport and Exercise , Massy Univ ersity, New Zealand.

ARTICLE INFORMATION

Hormozgan Medical Journal: 20 (3); e87681
Published Online: May 20, 2015
Article Type: Research Article
Received: April 29, 2014
Accepted: May 20, 2015

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Abstract

Introduction: Many of effects of exercise are mediated through cytokines. Inflammatory cytokines are increased by exercise and inhibited by anti-inflammatory cytokines. Meanwhile, vaccination leads to an increase in the inflammatory cytokines. To test the hypothesis that exercise training might alter the cytokine response to the influenza vaccine, we measured selected cytokines in elite boy gymnasts and non-exercising subjects who were administered with the influenza vaccine and compared these against non-vaccinated gymnasts.

Methods: Forty five healthy 9- to 12- years old children (30 gymnasts and 15 untrained) were assigned to training group (TG), training-vaccine group (TVG) and vaccine group (VG). The exercise protocol consisted of a 3 hours gymnastic practice, 3 days per week, for 8 weeks. TVG and VG group were immunized with trivalent influenza vaccine in the 0(Pre), 4 and 8th weeks. Pre- vaccination, 4 and 8 week blood samples were obtained in all subjects. Data were analyzed by one-way analysis of variance (ANOVA) and repeated measures tests. Significance level was accepted at P<0.05.

Results: After the intervention, significant decreases in IL-6 and IFN-γ were observed in all the groups (P<0.05). A significant difference, in IL-6 level between TVG and TG groups at week 8, and a significant differences in INF-γ level between TVG and TG groups at week 4 were also observed (P<0.05). There was not a significant increase in the IL-2 in TVG and TG groups, but a significant increase was observed in VG (P<0.05). A significant difference in IL-2 level between TVG and VG groups, between TG and VG at 4th week and between TVG and VG at 8th week was observed.

Conclusion: The results demonstrate that gymnastic training and vaccine in healthy children lead to reduction in inflammatory cytokines. This might explain the immature immune system response in children to both vaccination and exercise training.

Keywords

Influenza Vaccination Athletes Cytokine Exercise

© 2016, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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