The effects of creatine and carnitine supplementation on oxidative stress and inflammation in athletes

AUTHORS

Zohreh Mazloom 1 , Bahman Panahandeh 2 , * , Mohsen Salesi 3 , Mohammad Hasan Eftekhari 1

1 Associate Professor Department of Nutrition, Shiraz University, Shiraz, Iran.

2 PhD Student Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran.

3 Professor Department of Pysical Education, Shiraz University, Shiraz, Iran.

How to Cite: Mazloom Z, Panahandeh B, Salesi M, Eftekhari M H. The effects of creatine and carnitine supplementation on oxidative stress and inflammation in athletes, Hormozgan Med J. 2018 ; 18(5):e87699.

ARTICLE INFORMATION

Hormozgan Medical Journal: 18 (5); e87699
Published Online: December 30, 2013
Article Type: Research Article
Received: December 22, 2012
Accepted: December 30, 2013

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Abstract

Introduction: The present study was carried out to evaluate the effects of creatine and
carnitine supplementation on oxidative stress and inflammation in athletes.
Methods: In this single-blind randomized clinical trial 45 sportsmen were studied
selected from Velayat Sports Complex (in Shiraz) in this single-blind randomized clinical
trial. Then they were randomly divided into four groups supplemented with: a) Creatine,
b) Carnitine, c) Creatine and Carnitine and d) placebo for 28 days. Before and after the
intervention, blood samples were taken for measurement of oxidative stress (MDA and
GSHPx) and inflammation markers. Data were analyzed using SPSS/PC statistical
package (version 18). Paired t-test and ANOVA were used to compare mean values of
each groups.
Results: No statistically significant difference were found between the IL-6 and MDA
mean levels of the intervention groups and placebo group (P>0.05). Furthermore, no
statistically significant difference was noted in GSHPx mean values before and after
supplementation as well as in comparison to placebo group.
Conclusion: Based on the defined dose and duration of supplementation in the present
study, creatine and carnitine supplementation showed no effects on oxidative stress and
inflammation conditions either separately or simultaneously. Furthermore, no negative
and side effects were observed.

Keywords

Creatine – Carnitine - Oxidative Stress - Inflammation

© 2018, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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