Epithelial To Mesenchymal Transition Concept in Cancer: Review Article

AUTHORS

Mohammadreza Noori Daloii 1 , * , Tayeb Bahrami 2 , Mina Tabrizi 3

AUTHORS INFORMATION

1 Professor Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran.

2 MSc Student of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran.

3 Assistant Professor Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran.

ARTICLE INFORMATION

Hormozgan Medical Journal: 18 (2); e87830
Published Online: April 17, 2014
Article Type: Review Article
Received: January 26, 2014
Accepted: April 17, 2014

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Abstract

Owing to this fact that most of the mortalities in cancers are as a result of metastasis, study on
the involved pathways in metastasis including Epithelial to mesenchymal transition (EMT)
would be so critical and important. Up to date, several extensive studies have been carried out
to determine the correlation between EMT and cancer and their results have shown that the
EMT plays pivotal role in initiation of metastasis, invasion and recurrence of cancer besides
drug resistance. In this pathway which is occurred naturally during fetal development and
wound healing, cellular phenotype undergone various changes as well as increased in
capability of migration and invasion and the involved epithelial cells transform to semifibroblast
mesenchymal cells. There are some reports that have shown that mesenchymal cells
share the same gene expression and phenotype profile with cancer stem cells (CSCs). This
probability has enhanced the correlation between cancer and EMT. CSCs are tumor cells that
have the ability to self renew and tumorgenesis through differentiation. It was demonstrated
that this pathway has led to metastasis through CSCs induction. In this review article, it was
attempted to discuss about the current knowledge about the effect of EMT on cancer
development such as formation of CSCs, its regulatory factors and also EMT inhibition and
cancer treatment.

Keywords

Epithelil _ Mesenchymal Transition (EMT) - Cancer Stem Cells (CSCs) – Metastasis

© 2014, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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