Correlation between staining intensity of prostatic adenocarcinoma with P53 and Gleason's grading

AUTHORS

Mahmoud Heidari 1 , * , Seyed Abdollah Mousavi 2 , Shahram Zare 3

AUTHORS INFORMATION

1 Resident of Pathology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Assistant Professor Department of Pathology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Associate Professor Department of Community Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

ARTICLE INFORMATION

Hormozgan Medical Journal: 17 (3); e88128
Published Online: May 05, 2012
Article Type: Research Article
Received: November 11, 2011
Accepted: May 05, 2012

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Abstract

Introduction: Prostatic adenocarcinoma is the most common malignancy of internal
system and after lung cancer is the second cause of death in male. Genetic base of many
neoplasms is related to suppressor tumor gene such as P53. Therefore, we aimed in this
study, to assess the intensity of prostatic adenocarcinoma tissue staining with P53 staining
method and its relationship with Gleason grade.
Methods: In this cross-sectional study, during 2006 to 2008, all patients attending
pathology ward of Shahid Mohammadi hospital with diagnosed prostatic adenocarcinoma
enrolled for the study. Samples were stained with H & E staining and if adenocarcinoma
was confirmed they stained with P53 stain using immunohistichmistry (IHC) method and
severity of staining was recorded. We used colon cancer tissue for positive control and non
tumoral prostate tissue for negative control. Data were analyzed using descriptive method
and Chi-square test by means of SPSS.
Results: 30 patients aged between 60 and 91 with mean age of 77.10±8.5 enrolled in the
study. Grade of tumors vary from 2 to 10 and the most frequent grade was 7. Results show
that with increase in the Gleason grade, intensity of P53 staining also increases. (P<0.001)
Conclusion: Results demonstrated that there is a direct relationship between Gleason grade
and intensity of P53 staining.

Keywords

Adenocarcinoma - P53 - Prostate

© 2013, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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