Serum Leptin concentration and some cardiovascular risk factors in response to aerobic exercise and weight loss diet in sedentary women


Azam Ramezankhany 1 , Parvaneh Nazarali 2 , Parichehr Hanachi 3 , *


1 Master of Sport Sciences of Physical Education, Alzahra University, Tehran, Iran.

2 Assistant Professor Department of Physiology, Alzahra University, Tehran, Iran.

3 Assistant Professor Department of Biochemistry, Alzahra University, Tehran, Iran.


Hormozgan Medical Journal: 15 (3); e88483
Published Online: April 13, 2011
Article Type: Research Article
Received: June 21, 2010
Accepted: April 13, 2011




Introduction: Obesity is a complex disorder characterized by accumulation of excess
adipose tissue. Discovery of the hormone Leptin is catalyzed the field of obesity research by
demonstrating the existence of an afferent hormonal signal from adipose tissue to the central
nervous system for regulation of body fat mass. The aim of this study was to assay serum
Leptin concentration and some cardiovascular risk factors in response to aerobic exercise
and weight loss diet in sedentary women.
Methods: Thirty four women who were members of one of the diet therapy clinic in the
west of Tehran- Iran were recruited and divided randomly into 3 groups as following
groups: control group (C, n=10), low calorie diet (LCD, n=12) and aerobic exercise group
(EX, n=12). Leptin and lipid profiles were measured at baseline and at the end of the study.
The probability levels of significance were based on the 2 paired sample t-test and one way
ANOVA. Level of significance for all statistical tests were set at P<0.05.
Results: Serum Leptin concentrations (ng/dl) showed significant decrease (P<0.05) in
LCD (0.15±0.09), EX (0.37±0.06), after 16wk follow-up, and were different among
experimental groups (P<0.05). Blood lipids (TG, TC, LDL-C, HDL-C) were decreased
within experimental groups, however there weren’t significant changes within and between
groups. The ratio of HDL-C/LDL-C increased significantly within and between
experimental groups.
Conclusion: Serum Leptin concentrations showed significant changes within and between
exercise and diet groups. Dietary intervention or exercise intervention was poor achieved
improvements in cardiovascular risk factors. A combination of diet and exercise or longer
duration of diet and aerobic exercise intervention may be closely related to significant
decreases in lipid profiles.


Obesity – Diet - Cardiovascular Risk Factors - Cardiovascular System

© 2011, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. References are included in the PDF.