Serum Leptin concentration and some cardiovascular risk factors in response to aerobic exercise and weight loss diet in sedentary women
Hormozgan Medical Journal: October 01, 2011, 15 (3); e88483
April 13, 2011
Article Type: Research Article
June 21, 2010
April 13, 2011
P. Serum Leptin concentration and some cardiovascular risk factors in response to aerobic exercise and weight loss diet in sedentary women,
Hormozgan Med J.
Introduction: Obesity is a complex disorder characterized by accumulation of excess
adipose tissue. Discovery of the hormone Leptin is catalyzed the field of obesity research by
demonstrating the existence of an afferent hormonal signal from adipose tissue to the central
nervous system for regulation of body fat mass. The aim of this study was to assay serum
Leptin concentration and some cardiovascular risk factors in response to aerobic exercise
and weight loss diet in sedentary women.
Methods: Thirty four women who were members of one of the diet therapy clinic in the
west of Tehran- Iran were recruited and divided randomly into 3 groups as following
groups: control group (C, n=10), low calorie diet (LCD, n=12) and aerobic exercise group
(EX, n=12). Leptin and lipid profiles were measured at baseline and at the end of the study.
The probability levels of significance were based on the 2 paired sample t-test and one way
ANOVA. Level of significance for all statistical tests were set at P<0.05.
Results: Serum Leptin concentrations (ng/dl) showed significant decrease (P<0.05) in
LCD (0.15±0.09), EX (0.37±0.06), after 16wk follow-up, and were different among
experimental groups (P<0.05). Blood lipids (TG, TC, LDL-C, HDL-C) were decreased
within experimental groups, however there weren’t significant changes within and between
groups. The ratio of HDL-C/LDL-C increased significantly within and between
Conclusion: Serum Leptin concentrations showed significant changes within and between
exercise and diet groups. Dietary intervention or exercise intervention was poor achieved
improvements in cardiovascular risk factors. A combination of diet and exercise or longer
duration of diet and aerobic exercise intervention may be closely related to significant
decreases in lipid profiles.
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