Evaluation of results of fine needle aspiration and pathology of thyroid nodules in thyroidectomy Patients

AUTHORS

Seyed Mehrdad Solati 1 , * , Hamidreza Mirzania 2 , Seyed Alireza Sobhani 3 , Armaghan Eshraghian 4 , Vahid Mehrnush 4

1 Assistant Professor Department of Internal Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Assistant Professor Department of Surgery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Assistant Professor Department of Pathology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 Medical Students, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Solati S M, Mirzania H, Sobhani S A, Eshraghian A, Mehrnush V. Evaluation of results of fine needle aspiration and pathology of thyroid nodules in thyroidectomy Patients, Hormozgan Med J. 2011 ; 14(4):e88608.

ARTICLE INFORMATION

Hormozgan Medical Journal: 14 (4); e88608
Published Online: June 28, 2010
Article Type: Research Article
Received: October 31, 2009
Accepted: June 28, 2010

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Abstract

Introduction: The most common manifestation of thyroid malignancy is thyroid nodule.
In few studies, pathologic findings of malignancy were seen in patients who were
undergone thyroidectomy because of causes other than malignancy. The aim of this study
was the evaluation of the rate of malignancy in patients who undergone thyroidectomy.
Methods: In this retrospective multi central study, 765 out of 802 patients who had
undergone thyroidectomy in Bandar Abbas and Tehran Taleghani hospitals were evaluated
from 1376 till 1386. The FNA (Fine Needle Aspiration) results before operation and
pathologic results after operation were classified by AACE standard into benign (multi
nodular goiter,hoshimotoo's thyroiditis,simple or blood containing cysts, and follicular
adenomas) and malignant groups (papillary malignancy of thyroid, primary lymphoma of
thyroid, follicular malignancy of thyroid, hurtle cell malignancy of thyroid ,malignant
metastatic lesions). The data were analyzed with SPSS software.
Results: Preoperative cytology showed that 432 cases (73.8%) were benign, 79 of cases
(13.8%) were malignant, 55 (9.6%) suspicious, 5 (0.9%) inadequate and 11 (1.9%) were
unremarkable. Pathologic results of 222 patients (29%) were malignant and 534 (71%)
were benign. Specificity, sensitivity, positive and negative predictive value of FNA were
56.5, 97.6, 88.6 and 87.2, respectively.
Conclusion: In this study, FNA had low sensitivity for diagnosis of malignancy of
thyroid. Results showed that despite a negative FNA result, multiple FNAs and follow up
of thyroid are recommended.

Keywords

Thyroid Nodule – Thyroidectomy – Fine Needle Aspiration

© 2011, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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