Evaluation of 8-hour and 12-hour urine collection for detection of proteinuria in hypertensive women, Shariati hospital, 2004 - 2005
Hormozgan Medical Journal: April 01, 2008, 12 (1); e88845
August 15, 2007
Article Type: Research Article
July 22, 2007
August 15, 2007
P. Evaluation of 8-hour and 12-hour urine collection for detection of proteinuria in hypertensive women, Shariati hospital, 2004 - 2005,
Hormozgan Med J.
Introduction: Hypertensive disorders are common during pregnancy. Combination of
hypertension and proteinuria markedly increase prenatal morbidity and mortality. The
gold standard method for proteinuria assessment is 24-hour urine collection. This
survey is designed to determine the correlation between protein content of 8-hour and
24-hour urine collections.
Methods: This cross-sectional study was conducted on 65 pregnant women with
gestational age of over-20 weeks who were admitted for assessment of proteinuria in
obstetrics section of Shariati hospital, Bandar Abbas. Four urine samples were
collected from each patients including random sample, 8, 12 and 24-hour samples.
Randoms sample was examined qualitatively while other samples were assessed
quantitatively. Data was analyzed by Minitab software. Person's correlation coefficient
of 8-hour and 12-hour samples with 24-hour was calculated. Sensitivity, specificity,
negative and positive predictive values of random, 8-hour and 12-hour samples were
Results: Pearson’s correlation coefficients of 8-hour with 24-hour and 12-hour with
24-hour were 0.873 (P<0.01) and 0.89 (P<0.01), resoectuvely. 8-hour sample had
a sensitivity of 63% and negative predictive value of 82%. The 12-hour and random
samples predicted significant proteinuria with a sensitivity of 82% and 75%,
specificity of 88% and 63%, positive predictive values of 85% and 62%, and
negative predictive values of 86% and 76%, respectively. All patients with
proteinuria in 8-hour and 12-hour samples had significant proteinuria in 24-hour
Conclusion: There is a strong correlation between 8-hour and 12-hour with 24-hour
urine protein levels. Either the simultaneous positive or negative result for proteinuria
in 8-hour, 12-hour and random samples is of great significance in documentation or
ruling out of proteinuria in 24-hour sample collection.
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