Randomized comparison of vaginal dinoprostone and high dose oxytocin of Labor: Safety and Efficacy

AUTHORS

Minoo Rajaei 1 , * , Jhila Abedi Asl 2 , Maryam Nemati Katoli 3 , Shahram Zare 4

1 Hormozgan Fertility & Infertility Research Center, Department of Obstetrics & Gynecology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Assistant Professor, Department of Obstetrics & Gynecology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

3 Resident, Department of Obstetrics & Gynecology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 Associate Professor Department of Community Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Rajaei M, Abedi Asl J, Nemati Katoli M, Zare S . Randomized comparison of vaginal dinoprostone and high dose oxytocin of Labor: Safety and Efficacy, Hormozgan Med J. 2008 ; 12(2):e88935.

ARTICLE INFORMATION

Hormozgan Medical Journal: 12 (2); e88935
Published Online: August 14, 2007
Article Type: Research Article
Received: July 20, 2007
Accepted: August 14, 2007

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Abstract

Introduction: Unripe cervix is the most important factor in failure of labor
induction. This study is conducted to compare the efficacy and side effects of
Dinoproston and high dose Oxytocin as ripening agents in labor induction.
Methods: In this double blinded randomized clinical trial, 120 women with
unfavorable cervix who underwent labor induction were randomly assigned to
vaginal Dinoproston (9 mg) or intravenous high dose Oxytocin (6 miu/min)
groups. Initial 12 hours Bishop-Score, labor induction to labor duration, delivery
type, 1 and 5 minute APGAR, side effects on mother or neonate, hospitalization
duration and hospitalization costs were recorded. Data were analysed using t and
Chi-square tests by means of Minitab statistical software.
Results: The results showed that vaginal Dinoproston was effective in shortening
latent phase of labor (P<0.01). But, mean Bishop-Score over the initial 12
hours, the interval between labor induction to delivery, and side effects for
mother or neonate were not different between the two groups. Based on the
results, although hospitalization duration was not different between the groups,
hospitalization costs for Dinoproston group was significantly higher (P<0.05).
Conclusion: It seems that inspite of shortening the latent phase of labor in vaginal
Dinoproston group, it is not more effective than high dose Osytocin as an
adjuvant to labor induction in women with unfavorable cervix.

Keywords

Labor Induction - Cervix Ripening – Oxytocin - Dinoproston

© 2008, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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