Long term effects of kidney donation on blood pressure and kidney function of donors

AUTHORS

Mehrdad Moghimi 1 , * , Seyed Ali Marashi 1 , Fereshteh Kamani 1 , Ali Kabir 2 , Iraj Fazel 3 , Houman Ghasemzadeh 2 , Mohammad Ali Karimi 2

1 Assistant Professor, Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 General Practitioner, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Professor, Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

How to Cite: Moghimi M, Marashi S A, Kamani F, Kabir A, Fazel I, et al. Long term effects of kidney donation on blood pressure and kidney function of donors, Hormozgan Med J. 2008 ; 12(2):e88937.

ARTICLE INFORMATION

Hormozgan Medical Journal: 12 (2); e88937
Published Online: October 12, 2008
Article Type: Research Article
Received: August 19, 2007
Accepted: October 12, 2008

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Abstract

Introduction: Kidney transplantation from a live donor has many advantages, but
the donor should undergo a major surgery and accept potential morbidity and
mortality. In this study, we evaluated the long term effects of nephrectomy on renal
function and blood pressure of kidney donors.
Methods: In this cross-sectional study, we assessed 195 kidney donors. The
controls were 100 healthy individuals with two kidneys. The variables were age,
sex, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum
creatinine, creatinine clearance and proteinuria (all before and after kidney
donation) and time interval between donation and study. Data analysis was
accomplished using SPSS software, and paired t-test and Pearson correlation
coefficient were used for data analysis.
Results: Although serum creatinine was elevated at the time of study, but this
rise was not significant. SBP at the time of study was significantly greater than
the time of donation (P<0.001). Creatinine clearance at the time of study was
significantly lower than the time of donation (P<0.001). There was no
correlation between serum creatinine, creatinine clearance, SBP, DBP and age at
the time of kidney donation in men. Age at the time of kidney donation was
correlated with SBP and DBP and creatinine changes in women (P=0.001 and
P=0.002, respectively).
Conclusion: This study showed that nephrectomy does not impair renal function
in donor and does not lead to a progressive rise in blood pressure or urine protein
excretion up to 6.5 years after nephrectomy. Nevertheless, we suggest that
kidney donors should be selected after exact screening for potential risk factors of
renal disease.

Keywords

Kidney Transplantation - Donor - Blood Pressure - Serum Creatinine

© 2008, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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