Comparison of oxidative stress between patients with diabetes type 2 and healthy people

AUTHORS

Zahra Afzali 1 , * , Ali Asghar Pileh varian 2 , Ali Akbar Maleki rad 3

1 Master of Animal Physiology, Isfahan Payame Nour University, Isfahan, Iran.

2 Assistant Professor Department of Physiology, Isfahan Payame Nour University, Isfahan, Iran.

3 Candidate of Cognitive Neurosciences, Tabriz University, Tabriz, Iran.

How to Cite: Afzali Z, Pileh varian A A, Maleki rad A A. Comparison of oxidative stress between patients with diabetes type 2 and healthy people, Hormozgan Med J. 2008 ; 12(2):e88952.

ARTICLE INFORMATION

Hormozgan Medical Journal: 12 (2); e88952
Published Online: January 05, 2008
Article Type: Research Article
Received: August 08, 2006
Accepted: January 05, 2008

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Abstract

Introduction: Diabetes mellitus is one of the most common chronic diseases
around the world with increasing prevalence in Iran. Weakening of the
antioxidant defense system that accompanies this illness may lead to several
complications. In this study, we evaluated the parameters of oxidative stress in
patients with type 2 diabetes and compared them with healthy individuals.
Methods: In this cross-sectional study, 30 patients with type 2 diabetes who
referred to diabetes clinic in Arak city were included based on well-defined
inclusion criteria. They were compared with 30 individuals as the control group
who were matched by age and sex. The total antioxidant capacity of serum were
measured by Ferric Reducing Ability of Plasma technique in all partcipants. The
ThioBarbituric Acid method was used to estimate the amount of lipid
peroxidation and finaly, HU method was used to estimate the protein oxidation
(Thiol groups). The data were analyzed with SPSS software.
Results: The mean±SD of total antioxidant capacity of serum in patient and control
group were 2.743±0.08092 μm/ml and 1.927±0.04839 μm/ml respectively
(P<0.001). The mean±SD of lipid peroxidation in patient and control group were
3.2596±2.0650 nm/ml and 3.9050±3.5354 nm/ml, respectively that it was not
statistically significant. The mean±SD of protein oxidation (thiol) in patient and
control group were 0.2038±0.1307 and 0.3768±0.1487 μm/ml respectively
(P<0.001).
Conclusion: Our findings showed that the increased amount of total antioxidant
capacity of serum in diabetic patients was meaningful, but lipid peroxidation was not
significantly different between two groups that can be caused by taking natural and
medical antioxidants by patients. the production of free radicals in patients has been
increased and therefore the antioxidant defense system has been weakened.

Keywords

Free Radicals-Antioxidant-Oxidative stress-Type 2 Diabetes

© 2008, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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