The study of seroprevalence of human cytomegalovirus in healthy blood donors referring to Fars blood bank

AUTHORS

Mohammad Motamedifar 1 , * , Zahra Hashemizadeh 2 , Nahal Hadi 3 , Ardeshir Torab jahromi 4 , Leyla Kasraian 4

AUTHORS INFORMATION

1 Assistant professor, Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Master of Lab Sciences, Shiraz, Iran.

3 Instructor, Department of Bacteriology and Virology, Shiraz University of Medical mSciences, Shiraz, Iran.

4 Fars Blood Bank, Shiraz, Iran.

ARTICLE INFORMATION

Hormozgan Medical Journal: 12 (4); e89049
Published Online: February 05, 2008
Article Type: Research Article
Received: April 05, 2007
Accepted: February 05, 2008

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Abstract

Introduction: Human cytomegalovirus (HCMV) infection is most often asymptomatic
in immuno-competent individuals and has lifelong latency especially in leukocytes.
However, CMV is a major cause of infection and death in immuno-compromised
patients. Transfusion transmitted HCMV (TT-HCMV) can cause serious morbidity and
mortality in certain patients who are at risk. In this study, we evaluated the risk of TTHCMV
infection in a seroprevalence survey of HCMV.
Methods: In this descriptive cross-sectional study that was performed in a period
of eight months, the blood samples were collected from 360 healthy blood donors
referring to the Fars blood bank in Shiraz, Iran. The IgG and IgM antibodies to
HCMV were measured by enzyme linked immunosorbent assay (ELISA) test.
Results: Of 360 samples, IgG was detected in 356 sera (98.9%) samples and only
16 samples (4.4%) were IgM positive. No statistically significant association was
observed between seropositivitiy rate, age, sex, number of children and
educational level in the studied population.
Conclusion: The high prevalence of HCMV observed in this study confirms the
necessity of diagnosis, prevention and treatment of HCMV infection in immunocompromised
blood recipients in our community.

Keywords

Seroprevalence - Human Cytomegalovirus - Blood Donors

© 2009, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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