The effect of glutaminergic system on cardiovascular regulation of rat

AUTHORS

Masoumeh Hatam 1 , * , Amir Hesabi 2 , Majid Vatankhah 2 , Shahin Namdar 3 , Ali Nasimi 4

AUTHORS INFORMATION

1 Assistant Professor Department of Physiology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Medical Students, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Medical Lab Technician, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 Assistant Professor Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.

ARTICLE INFORMATION

Hormozgan Medical Journal: 10 (1); e89749
Published Online: September 23, 2005
Article Type: Research Article
Received: June 13, 2005
Accepted: September 23, 2005

Crossmark

CHEKING

READ FULL TEXT
Abstract

Introduction: The bed nucleus stria terminalis (BST) is a part of the limbic
system, which plays a role in regulation of heart beat and blood circulation. It
was recently shown that microinjection of L-glutamate in the BST elicits
cardiovascular depressive, but the role of glutamate receptor subtypes has not
been investigated yet. In this study, the role of glutamate receptor subgroups in
regulation of heart and blood circulation was investigated.
Methods: In this experimental study, experiments were performed on 36
anaesthetized and paralyzed rats with Urethane. Drugs were microinjected into
the BST in 50 nl volume using streotaxic system. Blood pressure and heart rate
were recorded before and after each injection. The average changes in the mean
arterial pressure and heart rate at different intervals, were compared both within
each case group and between case and control groups using analysis of variance.
Results: Microinjection of L-glutamate (0.25 M) into the BST, resulted in a
decrease of mean arterial pressure (-25.8±3.7 mmHg) and heart rate (-19.2±3.8
bpm). Injection of AP5, antagonist of glutamate NMDA receptor (2.5mM, 5mM)
and CNQX, antagonist of glutamate AMPA receptor (0.5, 1mM) had no
remarkable effect on the mean arterial pressure and heart rate.
Conclusion: This study shows that activation of glutaminergic system in BST
causes decrease of heart rate and mean arterial pressure, which is similar to
previous findings, but inhibition of AMPA and NMDA receptors had no effect on
mean arterial pressure and heart rate. These findings suggest that the
glutaminergic neurons of the BST are quiescent or have little activity to be
detected by microinjection of antagonists under these experimental conditions.

Keywords

Limbic System – Cardiovascular Physiology Rats – Receptors NMethyl- D-Asparate – Receptors AMPA

© 2006, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Fulltext
References
  • 1. References are included in the PDF.
  • COMMENTS

    LEAVE A COMMENT HERE: