Glioblastoma multiform in under 20 years age group: A ten years study in Kerman (1994-2003)


Reza Malekpour Afshar 1 , *


1 Assistant Professor, Department of Pathology, Kerman University of Medical Sciences, Kerman, Iran.


Hormozgan Medical Journal: 10 (1); e89766
Published Online: March 11, 2006
Article Type: Research Article
Received: October 18, 2004
Accepted: March 11, 2006




Introduction: Based on reviewing several large reports in literature, less than 3
percent of glioblastoma occurred in the first two decades of life. In the Asian
reports glioblastoma is more common than western reports. As there was no
similar report in Iran; this study was designed for evaluating the presence of
glioblastoma cases in first two decades of life.
Methods: In this cross-sectional study, 107 cases that had undergone
neurosurgical operation at Shahid Bahonar hospital (1994-2003) and the obtained
specimens were pathologically approved as glioblastoma multiform were
included. Information containing demography (age and sex), clinical data (main
presenting symptoms; tumor location), radiological and laboratory findings was
obtained from records in pathology and neurosurgery departments and the central
records of the hospital. The results were analyzed by SPSS software and chi
square statistical test.
Results: Of 107 cases of glioblastoma; 8 (7.4%) were under 20 years age group
and the male to female ratio was 3 to 1. Most of the tumors (87.5%) were
supratentorial and the temporal and parietal lobes were most commonly involved
main presenting symptoms included headache (87.5%); nausea or vomiting
(37.5%) and seizures (25%). Neutrophilic leukocytosis was the persistent
laboratory finding (62.5%).
Conclusion: The results show that glioblastoma multiform in Iran is more
prevalent in childhood than that in western communities. Clinical and Para
clinical findings are the same as other studies. Difference of corrected age based
values with other studies are not statistically significant, and it probably seems
that increased incidence of glioblastoma in first two decades of life is probably
related to population pyramid and a large number of young people in Iran.


Glioblastoma – Epidemiology – Kerman

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