Diagnostic value of serum level of creatine kinase after generalized tonic–clonic seizure

AUTHORS

Naser Zangiabadi 1 , * , Hosseinali Ebrahimi 2

1 Neurologist, Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Iran.

2 Associated Professor, Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Iran.

How to Cite: Zangiabadi N, Ebrahimi H. Diagnostic value of serum level of creatine kinase after generalized tonic–clonic seizure, Hormozgan Med J. 2005 ; 9(3):e90382.

ARTICLE INFORMATION

Hormozgan Medical Journal: 9 (3); e90382
Published Online: July 16, 2005
Article Type: Research Article
Received: October 03, 2004
Accepted: July 16, 2005

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Abstract

Introduction: The tonic-colonic attacks are the commonest from of epileptic
seizures. Diagnosis of generalized tonic-colonic seizures (TCS) by inspection of
seizures, history and paraclinic findings (electroencephalogram) are easy, but
diagnosis of pseudo seizures, syncope and TIA from TCS are occasionally
differentiated. Determination of serum level of prolaction after attack can help in
some of the cases. Determination of serum level of creatine kinase (CK) after
attack can help to differential diagnosis of generalized tonic-colonic seizures.
To determine the utility of serum CK measurement for diagnosing TCS and the
best time of measurement this study was designed.
Methods: In this descriptive study, serum CK was detected in 50 patients
admitted following an episode of TCS in 1,6,24 and 72 hours after attack. T-test
and analysis of variance was used for statistical analysis.
Results: Enzyme level was elevated in all of measured time. There wasn’t any
significant difference between time 1,6,24 and 72 h. In all times, except 72 h
enzyme level was significantly higher than maximum normal level (P<0.05).
Conclusion: Determination of serum level of CK is a useful test for evaluating
patients with TCS and it’s measurement to 24 hours after episode of seizure is
more accurately.

Keywords

Epilepsy – Epilepsy Tonic-Clonic – Creatine Kinase

© 2005, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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