LDL pattern and correlation between LDL size and HDL-C, Triglyceride in type II diabetic patients compared with normal individuals
Hormozgan Medical Journal: July 01, 2004, 8 (2); e90617
June 09, 2004
Article Type: Research Article
December 11, 2003
June 09, 2004
M. LDL pattern and correlation between LDL size and HDL-C, Triglyceride in type II diabetic patients compared with normal individuals,
Hormozgan Med J.
Introduction: Low density lipoprotein particles are non homogenous in terms of
their density and composition. Type B pattern is characterized by predominance
of small dense LDL particles. Investigations indicate that small dense LDL is
associated with an increased risk of coronary artery disease (CAD). This study is
designed to recognize additional effective parameter which could perhaps
contribute to increased risk of CAD in diabetics. LDL size was determined in
these patients. Pearson correlation coefficient and linear regression were used and
p<0.05 was considered as significant.
Methods: In this analytic study, LDL particle diameters were determined by non
denaturing gradient polyacrylamide gel electrophoresis in 81 patients with type II
diabetes mellitus and 81 healthy control subjects age 50 to 70 years. BMI was
calculated in all participants. Triglyceride (TG) and HDL-C concentrations were
measured enzymatically by analytical kits. In the study correlation between LDL
size and parameters such as BMI, age, sex, triglyceride, HDL-C and diabetic
status was also investigated.
Results: Based on results obtained, 59% of diabetic patients and 27% of controls
showed LDL pattern B. LDL size was significantly lower in diabetics than
controls (25.1±l.5 nm vs. 25.8±2.1 nm, p<0.05). Diabetics show significantly
higher TG (187.8±90.8 mg/dl vs. 145.6±69.7 mg/dl, p<0.01) and lower HDLC
(47.5±12.9 mg/dl vs. 57.1±14.3 mg/dl, p<0.05). Based on the results,
obtained LDL size shows significant inverse correlation with TG and diabetic
status and direct correlation with HDL-C concentration.
Conclusion: Diabetics showed 2-fold increase in frequency of LDL pattern B
which may explain increased risk of CAD in these patients.
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