Comparison of protective effect of two types of aerobic and intermittent training on breast cancer by TGFβ protein and Smad-3 gene and MMP2 in female mice

AUTHORS

Vahaid Moghaddam 1 , Maghsoud Peeri 1 , * , Mohammad Ali Azarbayjani 1 , Hasan Matin Homaee 1

1 Deprtment of Exercise Physiology,Central Tehran Branch,Islamic Azad University,Tehran,Iran.

How to Cite: Moghaddam V, Peeri M , Azarbayjani M A , Homaee H M. Comparison of protective effect of two types of aerobic and intermittent training on breast cancer by TGFβ protein and Smad-3 gene and MMP2 in female mice, Hormozgan Med J. 2017 ; 21(1):e87270. doi: 10.18869/acadpub.hmj.21.1.53.

ARTICLE INFORMATION

Hormozgan Medical Journal: 21 (1); e87270
Published Online: May 15, 2017
Article Type: Research Article
Received: February 08, 2017
Accepted: May 15, 2017
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Abstract

Introduction: The aim of this study was to compare the protective effects of two types
of aerobic and intermittent training on breast cancer as a result of TGFβ protein, Smad-3,
and MMP2 gene in female mice.
Methods: In the experimental study, a total of 24 female BALB/c mice after
Tumorigenesis by MC4-L2 cell line in the three groups; Control, Aerobic, and
Intermittent training groups, and under standard conditions were studied. Aerobic
continuous training group performed 60 minutes of running on a treadmill with intensity
of 60-65% VO2max, 5 days a week and high-intensity intermittent program included six
bouts alternates (3 minutes and 20 seconds with intensity of 85–90%VO2max and a
minute of recovery with intense 30-35%VO2max between each alternate) for a period of
10 weeks. Data using one-way ANOVA and Tukey's test at a significance level of
P<0.05 were analyzed.
Results: High-intensity intermittent training significantly increased expression of Smad-3
(P<0.03), and protein TGF-β (P<0.000) and decreased the expression of MMP-2
(P<0.000) in tumor tissue than in the control group. Aerobic training also significantly
increased the expression of Smad-3 (P<0.03) and protein TGF-β (P<0.000) and decreased
the expression of MMP-2 (P<0.04) in tumor tissue than in the control group. No
significant differences in gene expression Smad-3 and MMP-2 between training groups was
observed (P<0.05), However, there was significant differences in the TGF-β protein
between High-intensity intermittent training and aerobic training groups (P<0.05).
Conclusion: It seems that high-intensity intermittent and aerobic continuous training can
possibly be effective interventions to reduce breast cancer progression and there is not
much difference between the effects of two types of training.

Keywords

Breast Cancer Training TGFβ Smad MMP2

© 2017, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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