Structural changes of cardiac tissue in response to L-carnitine supplementation during endurance training in Wistar male rats toxicated by steroid anabolic hormone

AUTHORS

Fatemeh Habibpoor Karimabadi 1 , Asieh Abbasi Daloii 1 , * , Ahmad Abdi 1 , Seyed Javad Ziaolhagh 2

1 Department of Exercise Physiology,Ayatollah Amoli Branch,Islamic Azad University,Amol,Iran.

2 Department of Exercise Physiology,Shahrood Branch,Islamic Azad University,Shahrood,Iran.

How to Cite: Habibpoor Karimabadi F , Abbasi Daloii A , Abdi A, Ziaolhagh S J . Structural changes of cardiac tissue in response to L-carnitine supplementation during endurance training in Wistar male rats toxicated by steroid anabolic hormone, Hormozgan Med J. 2017 ; 21(2):e87276. doi: 10.29252/hmj.21.2.86.

ARTICLE INFORMATION

Hormozgan Medical Journal: 21 (2); e87276
Published Online: September 06, 2017
Article Type: Research Article
Received: April 18, 2017
Accepted: September 06, 2017
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Abstract

Introduction: The aim of this study was to investigate the structural changes of cardiac
tissue in response to L-carnitine supplementation and endurance training in Wistar male
rats toxicated by steroid anabolic hormone.
Methods: 36 male Wistar rats aged 8-12 weeks (weight 195±7.94g) were randomly
divided into six groups: Control, Non-treated, Boldenone (5 mg/kg), L-carnitine (100 mg
per kg), Endurance Training-L-carnitine and Sham group. Injection was conducted deep
in the hamstring once a week on an appointed day. The endurance training Protocol with
moderate intensity (50-55% maximal oxygen consumption) was performed for six weeks
and five times a week. After anesthesia, autopsy was performed and the cardiac tissue was
isolated.
Results: The results showed that boldenone causes damage to the heart tissue muscle and
heart muscle cells. Also, boldenone caused mild necrosis and congestion in the heart
tissue. However, the results showed that L-carnitine supplementation with endurance
training can decrease to normal levels and damage the heart tissue muscle and heart
muscle cells.
Conclusion: According to the findings, it seems that boldenone causes some structural
changes in the heart tissue, and possibly endurance training with L-carnitine supplementation
can reduce these changes.

Keywords

Androgenic Steroids L-carnitine Cardiac Exercise Training

© 2017, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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