High fat diets alter aerobic exercise and L-arginine effects in ischemia reperfusion induced renal injury in rats: gender related difference

AUTHORS

Effatsadat Vafamand 1 , Lotfali Bolboli 2 , Hossein Jahani-Azizabadi 3 , Ardeshir Talebi 4 , Mehdi Nematbakhsh 5 , *

1 Department of Physical Education and Sport Sciences, University of Mohaghegh Ardebili, Ardebil, Iran. Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Department of Physical Education and Sport Sciences, University of Mohaghegh Ardebili, Ardebil, Iran.

3 Department of Animal Science, University of Kurdistan, Sannandaj, Iran.

4 Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

5 Department of Physiology, Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

How to Cite: Vafamand E , Bolboli L , Jahani-Azizabadi H , Talebi A, Nematbakhsh M . High fat diets alter aerobic exercise and L-arginine effects in ischemia reperfusion induced renal injury in rats: gender related difference, Hormozgan Med J. 2017 ; 21(3):e87324. doi: 10.29252/hmj.21.3.178.

ARTICLE INFORMATION

Hormozgan Medical Journal: 21 (3); e87324
Published Online: October 28, 2017
Article Type: Research Article
Received: September 14, 2017
Accepted: October 28, 2017
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Abstract

Introduction: Renal ischemia reperfusion (I/R) caused kidney injury gender dependently.
High fat diet (HFD) contributes the development of renal dysfunction. L-arginine (L-arg)
and regular exercise are recognized to be protective in I/R and lipotoxicity. We compared
the role of aerobic exercise and L-arg supplementation against renal I/R in male and female
rats fed with HFD.
Methods: 54 adult male and female Wistar rats received standard control diet (control),
HFD, HFD plus L-arg (HFD±L-arg) or HFD plus aerobic exercise (HFD±EX) for 8
weeks. Then the animals were subjected to renal I/R by clamping renal vessels for period
of 45 min followed by 24 hour reperfusion.
Results: The serum levels of blood urea nitrogen (BUN) and creatinine (Cr), and kidney
tissue damage score (KTDS) were not significantly different between HFD and control
groups in two genders. However, the serum level of nitrite and kidney tissue level of
malondialdehyde (MDA) in HFD fed male rats increased significantly (P<0.05). Also,
kidney weight (KW) had significant decrement in HFD groups in comparison with control
groups in two genders (P<0.05). L-arg and aerobic exercise decreased the BUN levels and
KTDS in male rats after renal I/R (P<0.05), but such observations were not seen in female.
Conclusion: These results indicated that L-arg and aerobic exercise could ameliorate
renal I/R induced kidney injury in HFD male rats but not in female.

Keywords

Renal Ischemia Reperfusion High Fat Diet L-arginin Aerobic Exercise

© 2017, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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