High and low dose atorvastatin effects on high sensivity C-reactive protein in patient with acute coronary syndrome

AUTHORS

Ahmadnoor Abdi 1 , Shafei Rahimi 2 , Hossein Farshidi 3 , * , Vahid Vahdat Khah 4 , Elham Boushehri 5

1 epartment of Cardiology, Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 General Physician, Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Department of Cardiology, Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 Specialist in Internal Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

5 Department of Medical Education, Faculty of Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Abdi A , Rahimi S , Farshidi H , Vahdat Khah V , Boushehri E. High and low dose atorvastatin effects on high sensivity C-reactive protein in patient with acute coronary syndrome, Hormozgan Med J. 2017 ; 21(4):e87337. doi: 10.29252/hmj.21.4.218.

ARTICLE INFORMATION

Hormozgan Medical Journal: 21 (4); e87337
Published Online: December 24, 2017
Article Type: Research Article
Received: June 06, 2017
Accepted: December 24, 2017
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Abstract

Introduction: The effect of statins in reducing the risk of acute cardiovascular events is
not only due to their effect on serum cholesterol level but also from their antiinflammatory
effects, particularly those resulting from reducing of C - reactive protein
(CRP), is important. Atorvastatin dose and duration of treatment display different effects.
This study compared the effects of high and low doses atorvastatin in reducing serum
level of high sensitivity C reactive protein (hs-CRP).
Methods: One hundred patients with unstable angina or Non ST Elevation Myocardial
Infarction (NSTEMI) randomized into two groups. Group 1 (n=50) received atorvastatin
80, 20 and 20 mg in three days but group 2 (n=50) received atorvastatin 80 mg/day for
three days. High sensitivity C-Reactive protein was measured at admission time and after
three dose atorvastatin therapy.
Results: Hs-CRP significantly decreased from baseline to end of three doses treatment in
both groups (P=0.0001). However, the reduced level was greater in the group2 than group1
(-39.5% vs -31.2%, P=0.0185).
Conclusion: We found that both treatment methods have significantly effect on hs-CRP
in short term but high dose (80 mg/day) atorvastatin being associated with significantly
greater reductions in hs-CRP concentration.

Keywords

Atorvastatin Acute Coronary Syndrome CRP NSTEMI

© 2017, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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