Comparing the effectiveness of broad spectrum antibiotic prophylaxis with single agent antibiotic prophylaxis to prevent post-cesarean section infection

AUTHORS

Maryam Azizi Kutenaee 1 , Minoo Rajaei 1 , Aida Najafian 1 , Shahram Zare 2 , Maryam Iranfar 3 , * , Maryam Abbasian 4

1 Deprtment of Obstetrics and Gynecology , Infertility and Reproductive Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Department of Community Medicine , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Deprtment of Obstetrics and Gynecology, Infertility and Reproductive Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 Deprtment of Obstetrics and Gynecology , Infertility and Reproductive Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

How to Cite: Azizi Kutenaee M, Rajaei M, Najafian A , Zare S , Iranfar M , et al. Comparing the effectiveness of broad spectrum antibiotic prophylaxis with single agent antibiotic prophylaxis to prevent post-cesarean section infection, Hormozgan Med J. 2016 ; 20(5):e87384.

ARTICLE INFORMATION

Hormozgan Medical Journal: 20 (5); e87384
Published Online: October 06, 2014
Article Type: Research Article
Received: September 22, 2014
Accepted: October 06, 2014

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Abstract

Introduction: The rate of cesarean delivery is increasing. Infection is one of the most frequent and important complications of emergency cesarean section. Infection prophylaxis has an important role to reduce post-cesarean delivery complication. The aim of this study was to compare the effectiveness of broad spectrum antibiotic prophylaxis (Azithromycin+Cephalotin) with single agent antibiotic prophylaxis (Cephalotin) to prevent post-cesarean section infection in Shariati hospital patient since August 2012 to August 2013.

Methods: This clinical trial study was carried out in Shariati hospital of Bandar Abbas, Iran. 424 pregnant women were recruited and divided to two groups. Group 1 received Azithromycin and Cephalotin as a preoperative antibiotic prophylaxis and group 2 receives routine antibiotic regime (Cephalotin and placebo). To find any signs or symptoms of post-cesarean infection, patients were visited one mount after discharge. Collected data entered to SPSS software version 16 and descriptive and comparative test were performed.

Results: Our findings show that during one month after cesarian, in 4.3% (10 cases) of group 1 patients and 25.5% (55 cases) of group 2 patients, symptoms and signs of infection were observed. The difference between two groups was significant (P=0.000). We found no significant difference between demographic and other medical details.

Conclusion: Azithromycin have a significant effect on prevention of post-cesarean infection. Increasing the use of this broad spectrum agent as a part of antibiotic prophylaxis can decrease wound infection and other infectious complications of cesarean delivery.

Keywords

Antibiotic Section Infection

© 2016, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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