Effect of Citrullus Colocynthis Pulp on Renal Function in Streptozotocin-Induced Diabetic Rats

AUTHORS

Tayebeh Bagherizadeh 1 , Ali Gol 2 , * , Hakimeh Olomi 3

1 MSc of Department of Biology, Institute of Science and High Technology and Environmental Sciences, Kerman University of Medical Sciences, Kerman, Iran.

2 Associate Professor Department of Biology, Institute of Science and High Technology and Environmental Sciences, Kerman University of Medical Sciences, Kerman, Iran.

3 Associate Professor Department of Ecology, Institute of Science and High Technology and Environmental Sciences, Kerman University of Medical Sciences, Kerman, Iran.

How to Cite: Bagherizadeh T, Gol A , Olomi H. Effect of Citrullus Colocynthis Pulp on Renal Function in Streptozotocin-Induced Diabetic Rats, Hormozgan Med J. 2015 ; 19(4):e87559.

ARTICLE INFORMATION

Hormozgan Medical Journal: 19 (4); e87559
Published Online: August 18, 2013
Article Type: Research Article
Received: June 10, 2013
Accepted: August 18, 2013

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Abstract

Introduction: Diabetic nephropathy is one of the most serious microvascular
complications of diabetes and the main cause of end-stage renal disease. Various herbs have
been used to control diabetes complications. This study aimed at investigating the effect of
Citrullus colocynthis pulp on diabetes-induced renal damage in male rats.
Methods: A total of 36 rats were divided into 6 groups: 1- normal (N), 2- normal + 10
mg/kg colocynth (N+C10), 3- normal + 30 mg/kg colocynth (N+C30), 4- diabetic (D), 5-
diabetic+10 mg/kg colocynth (D+C10), and 6- diabetic+30 mg/kg colocynth (D+C30). The
rats received colocynth pulp through gavage for two weeks. The obtained data were
analyzed through ANOVA and Tukey test using SPSS 16.
Results: The diabetic rats showed a sharp rise in the volume of urine, clearance of albumin,
clearance of creatinine, and serum urea. Administration of colocynth in diabetic rats
improved the changes to normal.
Conclusion: The results of this study show that colocynth pulp has the potential to treat
diabetes and to prevent the relevant kidney damages.

Keywords

Diabetes Mellitus - Citrullus Colocynthis – Rat.

© 2015, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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