Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis

AUTHORS

Neda MotamediRad 1 , Meysam Rezaeishamirzadi 1 , Seyyed Hamid Moosavy 2 , Mohammad Shekari 3 , *

1 MSc Student of Medical Genetics, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Department of Internal Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Associate Professor Department of Genetics, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: MotamediRad N , Rezaeishamirzadi M , Moosavy S H , Shekari M. Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis, Hormozgan Med J. 2016 ; 19(6):e87645.

ARTICLE INFORMATION

Hormozgan Medical Journal: 19 (6); e87645
Published Online: July 09, 2014
Article Type: Research Article
Received: February 11, 2014
Accepted: July 09, 2014

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Abstract

Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic
ulcer. More than half of the world population is afflicted with Helicobacter, while only
20% of people show the clinical symptoms of the disease. Genes encoding the cytokines
interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This
study aims to analyze polymorphism in the IL-1B gene.
Methods: 107 individuals who showed the symptoms of chronic gastritis participated in
the treatment group. Individuals with no symptoms were considered as the control group.
IL-1B+3954C/T polymorphism was analyzed through PCR-RFLP.
Results: There is no association between the presence of the T allele in an IL-1B gene
whit peptic ulcer and chronic gastritis as compared with control group (OR=0.66,
CI=0.34-1.27, OR=0.75, CI=0.32-1.15) respectively.
Conclusion: Our results suggest that there is no association between IL-1B+3954 C/T
polymorphism and peptic ulcer disease and chronic inflammation.

Keywords

Polymorphism Interleukin 1B Peptic Ulcer Gastritis

© 2016, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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