Involvement of α-1-adrenergic receptors in central region of amygdala and the effects of cannabinoid agonist on inhibitory avoidance memory in male rats

AUTHORS

Azam Moshfegh 1 , * , Ahmadreza Yarabi 2 , Akram Tehranifard 3 , Katayoun Dastan 4

1 Assistant Professor Department of Biology, Islamic Azad Universit , Lahijan Branch, Lahijan, Iran.,

2 General Practitioner, Islamic Azad Universit, Lahijan Branch, Lahijan, Iran.

3 Assistant Professor Department of Biology, Islamic Azad Universit , Lahijan Branch, Lahijan, Iran.

4 Instructor Department of Biology, Islamic Azad Universit, Lahijan Branch, Lahijan, Iran.

How to Cite: Moshfegh A, Yarabi A, Tehranifard A, Dastan K. Involvement of α-1-adrenergic receptors in central region of amygdala and the effects of cannabinoid agonist on inhibitory avoidance memory in male rats, Hormozgan Med J. 2018 ; 18(5):e87693.

ARTICLE INFORMATION

Hormozgan Medical Journal: 18 (5); e87693
Published Online: December 30, 2013
Article Type: Research Article
Received: September 22, 2012
Accepted: December 30, 2013

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Abstract

Introduction: There are many similarities between memory impairment in patients suffering from Alzheimer and animals treated by Cannabinoids. The agonists of Cannabinoid receptors affect on a variety of memories and leanings. The present study aims to investigate the role of α-1-adrenergic receptors in central region of amygdala in state-dependent learning induced by WIN55,212-2 (cannabinoid agonist) in rats.
Methods: Cannulae placement was performed bilaterally in the central amygdala region of male rats. The rats were trained in the avoidance learning apparatus (step-down model). 24 hours after training, the memory was tested by measuring the lag time for stepping down the platform. Results: Injection of WIN55, 212-2 intra central amygdala (dose-dependent, 0.25, 0.5 μg/rat) post-training reduced lag time/latency for stepping down. Injection induced amnesia was reversed by pre-test administration of the same dose of WIN55, 212-2. It is called state-dependent learning. Pre-test intra-central injection of α-1-adrenoceptor agonist, Phenylephrine (0.5, 0.25 μg/rat) improved post-training WIN55, 212-2 (0.5 μg/rat) intra central injection induced retrieval impairment. But intra injection of Prazosin (0.5 μg/rat) 2 minutes before injection of WIN55, 212-2 (0.5 μg/rat) on the testing day inhibited WIN55, 212-2 state-dependent learning.
Conclusion: The results suggest that α-1-adrenergic receptors in central region of amygdala are involved in learning which dependent on the state induced by WIN55, 212-2.

Keywords

Cannabinoids - α1 - Adrenergic - Learning

© 2018, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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