Comparison of the effect of Dexamethasone - Metoclopramide combination and ondansetron in the prevention of nausea and vomiting in cesarean section under spinal Anesthesia

AUTHORS

Hashem Jarineshin 1 , Ferydoon Fekrat 2 , Saeid Kashani 3 , *

1 Assistant Professor Department of Anesthesiology,Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Anesthesiologyist and Critical Care Specialist , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Assistant Professor Department of Anesthesiology , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Jarineshin H, Fekrat F, Kashani S. Comparison of the effect of Dexamethasone - Metoclopramide combination and ondansetron in the prevention of nausea and vomiting in cesarean section under spinal Anesthesia, Hormozgan Med J. 2016 ; 20(2):e87777.

ARTICLE INFORMATION

Hormozgan Medical Journal: 20 (2); e87777
Published Online: April 12, 2016
Article Type: Research Article
Received: January 15, 2016
Accepted: April 12, 2016

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Abstract

Introduction: Nausea and vomiting is one of the complications of spinal anesthesia in cesarean section. The aim of this study was to compare the effects of dexamethasone-metocloprmide with ondansetrone on preventing nausea and vomiting during spinal Anesthesia for cesarean section.

Methods: In this study 212 pregnant women (17-45 years old) candidate for elective cesarean section with an ASA I-II were subjected to a randomized double blind clinical trial. Before spinal anesthesia was applied the first group received 8 milligram dexamethasone and 10 milligram metoclopramide intravenously, the second group received 8 milligram ondansetrone intravenously.

Results: There were no significant differences between the two groups regarding the demographic variables, and also heart rate, systolic and diastolic blood pressures at before neuroaxial block and at 1, 3, 5 and 10 minutes after block. )P>0.05). The Apgar score between the two groups was significantly different at the first (P=0.028), fifth (P=0.001) and twentieth minute (P=0.019). The overall incidence of nausea was 11.3% with no significant difference between the groups (P=0.665). No patient in the dexamethasone-metocloprimde group experienced any vomiting and in the ondansetrone group only 5 patients (4.7%) had vomiting (P>0.05).

Keywords

Metoclopramide Vomiting Ondansetron Spinal Anesthesia

© 2016, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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