Paraoxonase role in dyslipidemia in thyroid disease (review article)

AUTHORS

Seyed Mehrdad Solati 1 , * , Hamidreza Mahboobi 2

1 Assistant Professor Department of Internal Medicine, Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 General Practitioner, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Solati S M, Mahboobi H. Paraoxonase role in dyslipidemia in thyroid disease (review article), Hormozgan Med J. 2013 ; 17(1):e87948.

ARTICLE INFORMATION

Hormozgan Medical Journal: 17 (1); e87948
Published Online: July 23, 2012
Article Type: Review Article
Received: December 04, 2011
Accepted: July 23, 2012

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Abstract

Introduction: Thyroid disease e.g. hypothyroidism, hyperthyroidism, and subclinical
hypothyroidism are among the most common endocrine disorders. Dyslipidemia is prevalent
in thyroid diseases and lipid oxidation due to oxidative stress play an important role in the
pathogenesis of thyroid diseases. Antioxidant enzymes such as paraxonase have a protective
role in these patients and their activity is altered in these diseases. This paper reviews serum
level of these enzymes in thyroid disease and its association with cardiovascular disease.
Different studies have shown that lipid disturbances and antioxidant enzyme alteration
increases the risk of atherosclerosis and cardiovascular diseases.
We review the effect of treatment of thyroid disease on dyslipidemia and serum lipid
oxidation and alteration in antioxidant enzyme activity and paraxonase enzyme level

Keywords

Hypothyroidism – Patients - Dyslipidemia

© 2013, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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