Effects of bilateral tubal sterilization on serum oxidative stress and ovarian hormones in female rats

AUTHORS

Azita Faramarzi 1 , Behjat Seifi 2 , Hamidreza adeghipour Roudsari 3 , * , Alireza Shabanzadeh 4 , mahsa Sohani 5 , Mitra Ebrahimpoor 6

1 MSc Student of Physiology,Tehran University of Medical Sciences, Tehran, Iran.

2 Assistant Professor Department of Physiology,Tehran University of Medical Sciences, Tehran, Iran.

3 Professor Department of physiology,Tehran University of Medical Sciences, Tehran, Iran.

4 Associate Professor Department of Physiology,Tehran University of Medical Sciences, Tehran, Iran.

5 BSc of Laboratory Sciences,Tehran University of Medical Sciences, Tehran, Iran.

6 BSc of Biostatistics , Tehran University of Medical Sciences, Tehran, Iran.

How to Cite: Faramarzi A, Seifi B, adeghipour Roudsari H, Shabanzadeh A, Sohani M, et al. Effects of bilateral tubal sterilization on serum oxidative stress and ovarian hormones in female rats, Hormozgan Med J. 2013 ; 16(6):e88047.

ARTICLE INFORMATION

Hormozgan Medical Journal: 16 (6); e88047
Published Online: July 05, 2011
Article Type: Research Article
Received: May 15, 2011
Accepted: July 05, 2011

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Abstract

Introduction: Tubal Sterilization (TS) is one of the most common contraceptive methods. Some researchers believe that TL has complications, whereas there are contradictory reports about TS effects on ovarian function. The aim of this study was to evaluate the indices of oxidative stress and survey ovarian function after TS. Methods: The study groups consisted of 63 Sprague Dawley female rats. The study comprised of 2 protocols A and B. A Protocol: survey oxidative stress and ovarian hormones and B protocol: study of estrous cycle. Each of the protocols included control, sham and Tubal Sterilization (Pomeroy) groups. In protocol A, rats of PAB (Prooxidant-Antioxidant Balance), MDA (Malondialdhyde) 17 beta estradiol and progestrone were measured 15 and 45 days after intervention. In protocol B, 15 and 45 days after intervention, animal’s estrous cycle was followed for 15 days. Data were analyzed by means of SPSS. Software, using ANOVA and P<0.05 was considered statistically significant. Results: Our results showed that PAB and MDA significantly increased and estradiol and progesterone significantly decreased in rats undergone TS (P<0.05). Also TS caused irregularity in estrous cycle after 15 and 45 days. Conclusion: TS Increased oxidative stress level and decreased estradiol and progesterone of serum. Complications of TS may be due to increased oxidants and decreased estrogen and progesterone. By prescribing antioxidant, effects of TS can be reduced.

Keywords

Effects of bilateral tubal sterilization on serum oxidative stress and ovarian hormones in female rats

© 2013, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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