Herpes virus type 6 infection among children with Febrile Seizure, Bandar Abbas, Iran

AUTHORS

Ali Reza Moayedi 1 , * , Mohammad Mehdi Houshmandi 2 , Mohammad Bagher Rahmati 1 , Abdolmajid Nazemi 1 , Shahram Zare 3 , Seyed Reza Mirjalili 4

1 Assisstant Professor Department of Pediatrics, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Pediatricians, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Associate Professor Department of Community Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 Resident of Pediatric, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Moayedi A R, Houshmandi M M, Rahmati M B , Nazemi A, Zare S , et al. Herpes virus type 6 infection among children with Febrile Seizure, Bandar Abbas, Iran, Hormozgan Med J. 2013 ; 17(2):e88088.

ARTICLE INFORMATION

Hormozgan Medical Journal: 17 (2); e88088
Published Online: July 28, 2012
Article Type: Research Article
Received: May 22, 2012
Accepted: July 28, 2012

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Abstract

Introduction: Febrile seizure is a common disorder in children with an unknown etiology.
Viral infection such as herpes virus type 6 (HHV-6) has been suggested. The aim of this
study was to investigate the frequency of HHV-6 infection among children with febrile
seizure who had referred to Bandar Abbas children hospital.
Methods: A cross-sectional study conducted between 118 children aged 6 month to 5 years
old without any history of epilepsy and major infectious diseases. Demographic data and
family history of seizure, time of onset for febrile seizure and clinical characteristics
gathered. At the beginning of the study and 10 days later a serum sample obtained. IgG
against HHV-6 measured by ELISA method. Chi-square test was used to compare the
frequency of risk factors in two groups of infected and non-infected patients by HHV-6.
Results: 53 patients including 30 boys (56.6%) and 23 girls completed the study (mean
age: 19.5±9.9 months). The HHV-6 test was positive for 23 children and the remaining 30
were negative. There were not any significant differences in frequency of major or minor
risk factors of recurrent febrile seizure between two groups. 21.7% whom infected by
HHV-6 vs. 1 child in negative group had longer than 15 minutes postictal phase (P<0.05).
Conclusion: Forty three percent of the children with febrile seizure had infected by HHV-
6. There were not any significant differences in clinical characteristics of the disease and
frequency of risk factors for recurrent febrile seizure.

Keywords

Febrile Seizure - Human Herpes virus Type 6 – Exanthema Subitum

© 2013, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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