Relationship between coping ways with stress and IL-6 Immunologic biomarker in Coronary Heart Disease Patients

AUTHORS

Alireza Yousefi 1 , * , Ahmad Alipoor 2 , Farhad Shaghaghi 3 , Nasim Sharif 4

1 Associate Professor Department of Psychology, Payame noor University, Qom, Iran.

2 Professor Department of Psychology, Payam Noor University, Tehran, Iran.

3 Assistant Professor Department of Psychology, Payam Noor University, Tehran, Iran.

4 PhD of Psychology, Payam Noor University, Tehran, Iran.

How to Cite: Yousefi A, Alipoor A , Shaghaghi F, Sharif N. Relationship between coping ways with stress and IL-6 Immunologic biomarker in Coronary Heart Disease Patients, Hormozgan Med J. 2013 ; 17(2):e88098.

ARTICLE INFORMATION

Hormozgan Medical Journal: 17 (2); e88098
Published Online: March 05, 2012
Article Type: Research Article
Received: January 07, 2012
Accepted: March 05, 2012

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Abstract

Introduction: Coping ways with stress in coronary heart disease can lead to significant
changes in levels of IL-6 Immunologic Biomarker. The aim of this study was to examine the
relationship between coping ways with stress and IL-6 immunologic biomarker in coronary
heart disease patients.
Methods: In this experimental study, the subjects were 44 patients with confirmed
CHD, admitted to the private sector hospitals. At least one major coronary vessels with
more than 90% stenosis confirmed by angiography was inclusion crileria coping ways
questionnaire- Lazarus and Folkman and human IL-6 kit (Bender Med System
Manufacturing Co, Austria) with ELISA method measure were used. Statistical methods
included mean, standard deviation, Pearson correlation and multiple regression analysis.
Results: The results showed that there and significant positive correlation between
emotional focused coping ways and immunologic IL-6 biomarker significant negative
correlation between problem focused coping ways and Immunologic IL-6 biomarker, and
63% of total variance IL-6 biomarker are representation by coping ways. Coefficient of
Emotional focused coping ways according to T-test showed that these variables with 0.99
reliably can anticipate changes related to IL-6 biomarker. Continuous regression coefficient
showed that problem focused coping ways can significantly explain variance of IL-6
biomarker in coronary heart disease patients.
Conclusion: We concluded that using emotional focused coping ways may lead to an a
increases levels of IL-6. Using of problem focused coping ways may lead to decreased in
levels of IL-6.

Keywords

Stress – Interleukin 6 - Coronary Heart Disease - Cytokines

© 2013, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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