Evaluation of Troponin-T level in Neonate with Mechanical Ventilation

AUTHORS

Iraj Shahramian 1 , Mahin Badakhsh 2 , Abbasali Ramazani 3 , Elham Sharafi 4 , Noormohammad Noori 5 , *

1 Assistant Professor Department of Pediatrics, Zabol University of Medical Sciences, Zahedan, Iran.

2 Instructor Department of Midwifery, Zabol University of Medical Sciences, Zahedan, Iran.

3 Instructor Department of Statistics, Zabol University of Medical Sciences, Zahedan, Iran.

4 Resident of Ophtalmology, Research Center for Children and Adolescents Health, Zahedan University of Medical Sciences, Zahedan Iran.

5 Professor Department of Pediatrics, Research Center for Children and Adolescents Health, Zahedan University of Medical Sciences, Zahedan Iran.

How to Cite: Shahramian I, Badakhsh M, Ramazani A, Sharafi E, Noori N. Evaluation of Troponin-T level in Neonate with Mechanical Ventilation, Hormozgan Med J. 2013 ; 17(4):e88183.

ARTICLE INFORMATION

Hormozgan Medical Journal: 17 (4); e88183
Published Online: October 02, 2012
Article Type: Research Article
Received: April 17, 2011
Accepted: October 02, 2012

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Abstract

Introduction: Troponin- T is the best biological marker of heart injuries, that isn’t affected
by sex, age, birth weight and gestational age. Myocardial damage in infancy is a risk factor
eventual cardiac disease. This study carried out for cardiac evaluation of neonates with
mechanical ventilation by Troponin T.
Methods: This case-control study carried out on 60 infants that were admitted in neonate
intensive care unit of Amir Almomenin hospital, Zabol, Iran. Neonates were enrolled in 2
groups: those who were supported with ventilator as cases and those who were not
supported with ventilator as control group. We assayed the serum samples from neonates for
Troponin T for myocardial injury. Data was analyzed using Pearson correlation, Mann-
Whitney and Chi-square tests by SPSS software and significance level of 0.05.
Results: Troponin T levels in case group was significantly different than it in control group
at the beginning of the study and 24 hours after that (P<0.05). Generally, Troponin T level
in case group was significantly higher than it in control group.
Conclusion: We conclude that evaluation of newborn with mechanical ventilation enhances
the possibility of occult and clinically myocardial injury. The results, in this study, suggest
that Troponin T is a useful and early marker for myocardial injury.

Keywords

Troponin T – Newborn - Myocardial Injury

© 2013, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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