Association of leptin gene (rs 7799039) polymorphism and colorectal cancer

AUTHORS

Khatoun Karimi 1 , Akram Safaei 2 , * , Maral Arkani 1 , Mohsen Vahedi 3 , Reza Mohebi 4 , Reza Fatemi 5 , Mohammad Vafaei 6 , Mohammadreza Zali 6

1 MSc of Microbiology, Research Center for Gastroenterology and Liver Disease of Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 PhD Student of Proteomix, Research Center for Gastroenterology and Liver Disease of Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 PhD Student of Bilogical Statistics, Research Center for Gastroenterology and Liver Disease of Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 PhD of Medical Virology, Research Center for Gastroenterology and Liver Disease of Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Associate Professor Department of Internal Medicine, Research Center for Gastroenterology and Liver Disease of Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

6 Professor Department of Internal Medicine, Research Center for Gastroenterology and Liver Disease of Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

How to Cite: Karimi K, Safaei A, Arkani M, Vahedi M, Mohebi R, et al. Association of leptin gene (rs 7799039) polymorphism and colorectal cancer, Hormozgan Med J. 2013 ; 17(5):e88200.

ARTICLE INFORMATION

Hormozgan Medical Journal: 17 (5); e88200
Published Online: September 04, 2012
Article Type: Research Article
Received: December 25, 2011
Accepted: September 04, 2012

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Abstract

Introduction: Studies show polymorphism in leptin gene cause increase in level of leptin
hormone and increased level of leptin hormon is associated with abosity, insulin resistance
and increased risk of colorectal cancer. The aim of this study was to assess the incidence of
leptin gene polymorphism rs 7799039 in Tehran and to investigate the influence of this
polymorphism in increased risk of colorectal cancer.
Methods: In this case-control study, genotyping of the leptin gene were determined in
series of 108 colorectal cancer patients and 108 controls by using polymerase chain reaction
and restriction fragment length polymorphism genotyping assays (PCR-RFLP).The
statistical analysis was done with SPSS 16.
Results: The frequency of A allele in patient group and control group were 52.8% and
62.5%, respectively. In this study allele frequency showed significant deference between
patient group and control group (P=0.04). In patient group frequency of GG, GA, AA for
leptin gene were 19.4%, 55.6% and 25%, respectively and in control were 38%, 49.1%
and 13%.
Conclusion: These findings suggest that polymorphism Leptin rs 7799039, is associated
with decreased risk of CRC.

Keywords

Colorectal Cancers - Leptin - Polymorphism

© 2013, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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