The effects of red clover on hot flushes in post-menopausal women

AUTHORS

Kobra Salehi 1 , Soheila Ehsanpour 2 , * , Behzad Zolfaghari 3 , Zahra Salehi 4 , Mansoureh Honarjoo 5

1 Instructor Department of Midwifery, Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Instructor Department of Medical Educatiion, Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Assistant Professor Department of Pharmacognosy, Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

4 MSc Student of Nursing, Isfahan University of Medical Sciences, Isfahan, Iran.

5 BSc of Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

How to Cite: Salehi K, Ehsanpour S, Zolfaghari B, Salehi Z, Honarjoo M. The effects of red clover on hot flushes in post-menopausal women, Hormozgan Med J. 2014 ; 17(6):e88263.

ARTICLE INFORMATION

Hormozgan Medical Journal: 17 (6); e88263
Published Online: December 17, 2012
Article Type: Research Article
Received: January 13, 2012
Accepted: December 17, 2012

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Abstract

Introduction: Hot flushing is one of the most common symptoms related to menopause
which can lead to sleep deprivation, physical and psychological tiredness and disturbances in
interpersonal relationships. In the recent years, tendency and desire toward alternative
treatments, especially phytoestrogens, in relieving this symptom have been increased.
Considering that red clover is the rich source of phytoestrogens, the present study
investigated the effect of red clover on hot flushes in post-menopausal women.
Methods: This was a clinical randomized, triple-blind, placebo-controlled trial. 72 eligible
menopausal women after two weeks of monitoring and determination of baseline severity of
hot flushes, were randomized blindly to receive either placebo or 45 mg of red clover
isoflavones capsules for eight weeks. Hot flushes were recorded weekly by the study
subjects via using hot flushes severity of Kupperman Menopause Index (KMI). Mann-
Whitney and Friedman tests were used for between and within the groups' comparisons in
frequency of hot flushes. Data analysis was performed using SPSS version 18.
Results: A total of 55 women completed the study, 28 subjects in the red clover and 27 in
the placebo group. In both of the study groups, the frequency of hot flushes had a significant
difference at the end of the second, sixth and tenth weeks (P=0.001). At the end of the 10th
week, there was a significant difference in frequency of hot flashes between the groups
(P=0.04).
Conclusion: Generally, the present study showed that red clover supplementation had
desirable and significant effects on hot flushing.

Keywords

Hot Flushes - Phytoestrogens – Menopause

© 2014, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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