The effect of inhaled corticosteroids on height growth velocity of 6-12 years old asthmatic children

AUTHORS

Kourosh Mohammadi 1 , Mohammad Hasan Keshavarz 2 , * , Shahram Zare 3

1 Assistant Professor Department of Pediatrics, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Pediatrician, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Associate Professor Department of Community Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Mohammadi K, Keshavarz M H, Zare S . The effect of inhaled corticosteroids on height growth velocity of 6-12 years old asthmatic children, Hormozgan Med J. 2011 ; 15(1):e88376.

ARTICLE INFORMATION

Hormozgan Medical Journal: 15 (1); e88376
Published Online: September 04, 2010
Article Type: Research Article
Received: May 31, 2010
Accepted: September 04, 2010

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Abstract

Introduction: Inhaled corticosteroids are recognized as the most effective antiinflammatory
therapy in patient with asthma. Further studies must be done about potential
adverse effects of inhaled corticosteroid on linear growth in asthmatic children. This study
aims to assess the effects of treatment with Inhaled corticosteroids on linear growth in 6-12
years old asthmatic children.
Methods: In a randomized clinical trial study, we randomly selected 70, 6-12 years old,
asthmatic children as cases and 70 healthy children as control group. The asthmatic children
were classified into two groups, one group included 35 asthmatic patients on
beclomethasone 450 microgram per day and another group included 35 asthmatic patients
on fluticasone 250 microgram per day. Height of all children was measured with standard
stadiometery in first visit, six month and one year later. The data were analyzed using t,
Chi- Square and analysis of variance tests.
Results: There were 106 boys (75.7%) and 34 girls (24.3%). mean age was 7.35±1.09
without any significant difference between three groups. There was no significant difference
in sex and duration of ICSs consumption among the groups. Mean of height growth, 6
month after ICSs prescription was 3.26 cm in beclomethasone group, 2.9cm in fluticasone
group and 3.01 cm in control group. Mean of height growth one year after ICSs
prescription was 6.21 cm in beclomethasone, 6.07 cm in fluticasone group and 5.92 cm in
control group. The differences were not statistically significant.
Conclusion: We observed no significant negative effect of usage of Inhaled corticosteroids
(Beclomethasone 450 microgram per day and fluticasone 250 microgram per day) for 3 to 6
months on linear growth of asthmatic children.

Keywords

Asthma - Beclomethasone – Fluticasone - Growth

© 2011, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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