Infective endocarditis in intravenous drug users, evaluation of clinical and para-clinical presentation

AUTHORS

Mehdi Besharat 1 , * , Farhad Abbasi 2 , Seyed Rahman Khoshhal 2

1 Assistant Professor Department of Infectious Disease, Infectious & Topical Medical Research Center, Shahid Beheshti Medical University, Tehran, Iran.

2 Infectious Disease Specialist, Bushehr University of Medical Sciences, Bushehr, Iran.

How to Cite: Besharat M, Abbasi F, Khoshhal S R. Infective endocarditis in intravenous drug users, evaluation of clinical and para-clinical presentation, Hormozgan Med J. 2011 ; 15(2):e88474.

ARTICLE INFORMATION

Hormozgan Medical Journal: 15 (2); e88474
Published Online: February 16, 2011
Article Type: Research Article
Received: May 31, 2010
Accepted: February 16, 2011

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Abstract

Introduction: 60 percent of hospitalization causes of intravenous drug users are infection,
of which 5 to 15 percent of them due to endocorditis. Infective endocorditis is a common
infection among intravenous drug users and can cause high mortality and morbidity. This
study was conducted to evaluate clinical and para-clinical presentations of drug users.
Methods: In a descriptive study we evaluate 33 narcotic addicts with documented infective
endocarditis in two tertiary care hospitals in Tehran, Iran; Imam Hosein and Loghman
Hakim hospitals during 2002-2008. Demographic information, clinical manifestation,
radiologic, laboratory and echocardiographic data were evaluated. The data were analysed
using SPSS software.
Results: 82% of patients were in 20-40 year old age group. 52% of the cases were referred
to the hospital with main complain of fever and cough and 27% with pain and fever. Fever
was observed in 91% of the patients. Positive blood culture was observed in 9 cases and
negative blood culture in 14 cases. The most common involved valve was tricuspid.
Mortality rate was 45%.
Conclusion: Endocarditis should be considered in intravenous drug users when they
present with fever. Blood culture may be negative due to previous use of antibiotics and
poor technique of culture.

Keywords

Endocarditis - Drug Users - Clinical Manifestation

© 2011, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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