A pilot Seroepidemiologic study of HTLV in thalassemia, hemophilia, and hemodialysed patients in Hormozgan

AUTHORS

Farshid Abedi 1 , Majid Yavarian 2 , * , Arash Shakibzadeh 3 , Bahman Khalvati 3 , Amirhassan Asadi 4

1 Infections Diseases Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Assistant Professor Department of Genetics, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

4 Hormozgan Blood Bank, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Abedi F, Yavarian M, Shakibzadeh A, Khalvati B, Asadi A. A pilot Seroepidemiologic study of HTLV in thalassemia, hemophilia, and hemodialysed patients in Hormozgan, Hormozgan Med J. 2009 ; 13(2):e88635.

ARTICLE INFORMATION

Hormozgan Medical Journal: 13 (2); e88635
Published Online: February 15, 2009
Article Type: Research Article
Received: July 11, 2007
Accepted: February 15, 2009

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Abstract

Introduction: Transmission of blood borne infections is common among the
multitransfusion patients such as Thalassemia, Hemophilia and Hemodialysis patients.
Human T-Lymphotropic Virus (HTLV) is one of the Retroviruses which are
transmitted by blood and its products. In Iran, HTLV is endemic only in Khorasan
province. In order to assess the possibility of the virus transmission and its clinical
impacts, in this study, we consider the seroepidemiological patterns of HTLV
infections in a group pf thalassemia, Hemophilia and hemodialysis patients from
Hormozgan.
Methods: In this seroepidemiological study, 210 patients, including 163 thalassemias,
40 hemodialysis patients and 7 hemophilia (98 female, 112 male) with the age range of
9 to 79 years were analyzed. Their plasma was tested for detection of antibody against
HTLV by ELISA method and was confirmed by Western blot and PCR methods.
Results: Anti-bodies against HTLV type 1 were detected in 3.06% of patients
which was higher than its prevalence in healthy individuals. All positive cases
were thalassemia patients. No positive case was among hemodialysis or
hemophilia patients. HTLV type 2 was not found in this study.
Conclusion: This study shows that multi-transfusion patients were infected probably
via blood transfusion or hemodialysis and there is possibility that HTLV virus is not
restricted to Khorasan Province.

Keywords

Thalassemia – Hemophilia – Hemodialysis – HTLV-I

© 2009, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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