Effects of clonidine on the hemodynamic changes of electroconvulsive therapy

AUTHORS

Hashem Jarineshin 1 , * , Saeid Kashani 1 , Ghasem Sobhani 2 , Esmaeil Alimolaei 3

1 Assistant Professor Department of Anesthesiology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Instructor Department of Anestesiology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Anesthetist, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Jarineshin H, Kashani S, Sobhani G, Alimolaei E. Effects of clonidine on the hemodynamic changes of electroconvulsive therapy, Hormozgan Med J. 2008 ; 12(1):e88833.

ARTICLE INFORMATION

Hormozgan Medical Journal: 12 (1); e88833
Published Online: December 13, 2007
Article Type: Research Article
Received: August 01, 2006
Accepted: December 13, 2007

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Abstract

Introduction: Electroconvulsive therapy (ECT) is an effective treatment for many
psychological disorders, mainly major depression and schizophrenia which is often
associated with some complications such as hypertension, tachycardia arrhythmia and
even myocardial infarction.
Various methods have been used for prevention or control of these cardiovascular side
effects. The aim of this study was evaluating the effect of oral clonidine as
premedication on hemodynamic response after ECT.
Methods: This double-blind clinical trial was performed on 100 patients aged 15-50
years with ASA I and II who were candidates for ECT.
Prior to ECT, patients were randomly divided to 2 equal groups. The first group
(N=50) received oral clonidine and the second group (N=50) received placebo as
premedication. After baseline measurement of heart rate, systolic and diastolic blood
pressures, similar induction of anesthesia was done in both groups. Then ECT was
induced. The patients heart rate, systolic and diastolic blood pressures were measured
again 2 minutes after termination of convulsion. Data was analyzed by t-test p<0.05
was considered statistically significant.
Results: Regarding age, sex and baseline hemodynamic parameters, the patients
were similar in both groups. Mean systolic and diastolic blood pressures after ECT
were significantly lower in clonidine group (p<0.05), but there was no significant
difference between heart rate after ECT in the two groups.
Conclusion: According to these results, we recommend usage of clonidine as
premedication before ECT.

Keywords

Clonidine – Electroconvulsive therapy (ECT) – Hemodynamic changes

© 2008, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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