Responsivity to phototherapy in patients with vitiligo in Shahid Faghihi Hospital, Shiraz

AUTHORS

Rahmatallah Salmanpoor 1 , * , Mohammadreza Razmavar 2 , Leyla Niknam 3

1 Associate Professor Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Resident, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.

3 General Practitioner, Shiraz University of Medical Sciences, Shiraz, Iran.

How to Cite: Salmanpoor R, Razmavar M, Niknam L. Responsivity to phototherapy in patients with vitiligo in Shahid Faghihi Hospital, Shiraz, Hormozgan Med J. 2008 ; 12(1):e88847.

ARTICLE INFORMATION

Hormozgan Medical Journal: 12 (1); e88847
Published Online: October 14, 2007
Article Type: Research Article
Received: April 24, 2007
Accepted: October 14, 2007

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Abstract

Introduction: Psoralen plus ultraviolet A (PUVA), regardless of it's hazards to
physician and patients, is considered to be treatment of choice for subtotal vitiligo. This
study attempts to evaluate the efficacy of PUVA in treatment of patients with vitiligo.
Methods: We have performed a descriptive-analytic study on 30 patients with vitiligo
who received PUVA therapy during 2004-2005 in phototherapy center of Doctor
Faghihi hospital, Shiraz and evaluated their response to treatment. Data was analyzed
by Mann-Witney statistical test and spearman correlation coefficient..
Results: Overall, 22 patients (73.4%) showed some improvement; 18 patients
experienced a repigmentation of 51-75% and 4 patients achived greater than 75%
repigmentation. Trunk, face and neck lesions showed better repigmentation than
other areas, whearas hands and feet were generally refractory to treatment. Sex of
the patients and disease duration had no influence on PUVA-included
repigmenttation, but age at onset of the disease had negative correlation with degree
of repigmentation and dose of PUVA had positive correlation with degree of
repigmentation.
Conclusion: Distribution of vitiliginous lesions must be taken into consideration
before the initiation of PUVA therapy, as the response to treatment varies greatly at
different body sites; Hands and feet lesions are refractory to PUVA. Trunk, face and
neck lesions show the best responsiveness.

Keywords

Vitilligo – PUVA - Repigmentation

© 2008, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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