The relationship between Indicators of plasma oxidative stress and photo aging

AUTHORS

Reza Ghaderi 1 , * , Asghar Zarban 2 , Hamideh Babaeian 3 , Monireh Safar Yazdi 3 , Gholamreza Sharifzadeh 4

1 Associate Professor Department of Dermatology, Birjand University of Medical Sciences, Birjand, Iran.

2 Assistant Professor Department of Biochemistry, Birjand University of Medical Sciences, Birjand, Iran.

3 Medical Student, Birjand University of Medical Sciences, Birjand, Iran.

4 Instractor Department of Epidemiology, Birjand University of Medical Sciences, Birjand, Iran.

How to Cite: Ghaderi R, Zarban A, Babaeian H, Safar Yazdi M, Sharifzadeh G. The relationship between Indicators of plasma oxidative stress and photo aging, Hormozgan Med J. 2009 ; 12(4):e88975.

ARTICLE INFORMATION

Hormozgan Medical Journal: 12 (4); e88975
Published Online: May 01, 2008
Article Type: Research Article
Received: July 19, 2006
Accepted: May 01, 2008

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Abstract

Introduction: Photo aging is significantly different from chronological aging in
both clinical and histological appearances. It has been suggested that oxidative
stress generated by ultraviolet radiation (UVR), leads to photo aging over a long
time period. This study was conducted to determine the relationship between the
indicators of plasma oxidative stress and photo damaged skin in patients who
referred to dermatology clinic in Birjand city.
Methods: In this case-control study, 33 patients with photo aging and 33 controls
(matched age and gender) were recruited after confirmation of the diagnosis by a
dermatologist. Mean time of sun exposure in patient and control groups was
measured separately. Plasma total antioxidant capacity, lipid per oxidation and
thiol groups' levels (as indicators of oxidative stress) were measured in case and
control groups. The collected data were analyzed using SPSS (ver.12) software.
Results: Mean time of sun exposure in case group (5.5 ± 2.1 hour per day) was
higher than control group (1.9 ± 1.2 hour per day) (p<0.001). Mean of plasma
lipid per oxidation levels in case group (3.4 ± 1.1 mmol/lit) was higher than
control group (2.80 ± 0.67 mmol/lit) (p<0.003). There was no significant
difference between mean of plasma total antioxidant capacity and mean of plasma
thiol groups in case and control groups.
Conclusion: The results of this study suggest that a relationship exists between
plasma lipid per oxidation levels and photo aging.

Keywords

Photo aging - Antioxidant - Plasma - Lipid Per oxidation

© 2009, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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