Leukocyturia, another clue to inflammation in acute coronary syndrome

AUTHORS

Rahimeh Skandarian 1 , * , Raheb GHorbani 2 , Jafar Toosi 3 , Mojtaba Malek 1 , Alireza Motevali 4 , Mohammadreza Seifollahi 4 , Mehdi Babaei 1 , shahrokh Moosavi 1 , Mehrdad Zahmatkesh 5

1 Assistant Professor Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran.

2 Assistant Professor Department of Biostatistic, Semnan University of Medical Sciences, Semnan, Iran.

3 Pathologist, Semnan University of Medical Sciences, Semnan, Iran.

4 General Practitioner, Semnan University of Medical Sciences, Semnan, Iran.

5 Nurse, Semnan University of Medical Sciences, Semnan, Iran.

How to Cite: Skandarian R, GHorbani R, Toosi J, Malek M, Motevali A, et al. Leukocyturia, another clue to inflammation in acute coronary syndrome, Hormozgan Med J. 2007 ; 11(1):e89072.

ARTICLE INFORMATION

Hormozgan Medical Journal: 11 (1); e89072
Published Online: October 19, 2006
Article Type: Research Article
Received: June 06, 2005
Accepted: October 19, 2006

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Abstract

Introduction: Cronary artery disease is the main cause of mortality in developed
countries. Classic risk factors have not been able to explain epidemiologic variants in
this disease, hence other risk factors including systemic infections are under survey.
This study was designed to evaluate the possible role of local and systemic infections
in producing acute coronary syndrome (ACS).
Methods: This prospective case-control study was conducted on all patients admitted
with ACS diagnosis (unstable angina, myocardial infarction) in CCU ward of
Fatemieh hospital, Semnan. The control group was selected among those patients
admitted to internal ward due to noninfectious disease. Overall 200 cases and 200
controls entered the survey. Leukocyturia, hematuria and urine culture results were
obtained and compared. SPSS software, t-test and Chi-square test were used for data
analysis and P<0.05 was considered significant.
Results: The case and control groups had no significant difference considering
age and sex. Mean age of cases and controls were 60.03±19.32 and 59.9±17.2
years, respectively. Hematuria was seen in 18.5% of cases and 5% of control
group (P<0.0001). Albuminuria was seen in 6% of cases and 7% of controls
which was not a meaningful difference.
Conclusion: The results show that evidences of mild urinary tract infection such
as leukocyturia and hematuria are seen more prevalent in patients with ACS than
control group. This can be a clue to a mild underlying inflammation, infection
due to uncommon microorganisms or leukocyturia and hematuria during a
systemic infectious process.

Keywords

Pyuria - Hematuria – Angina Unstable – Myocardial Infection – Risk Factors

© 2007, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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