Stress oxidant level and memory deficit in over 70 years old population

AUTHORS

Hamidreza Roohafza 1 , * , Seyed Ghafour Moosavi 2 , Masoumeh Sadeghi 1 , Babak Sabet 3

1 Assistant Professor Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Assistant Professor Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Resident Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

How to Cite: Roohafza H, Moosavi S G, Sadeghi M, Sabet B. Stress oxidant level and memory deficit in over 70 years old population, Hormozgan Med J. 2007 ; 11(2):e89380.

ARTICLE INFORMATION

Hormozgan Medical Journal: 11 (2); e89380
Published Online: March 14, 2007
Article Type: Research Article
Received: May 03, 2005
Accepted: March 14, 2007

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Abstract

Introduction: Increase in life expectancy in communities tends to increase in
number of elderly people and increase in prevalence of memory deficit. This study is
aimed to investigate the relationship between memory deficit and some related factors
such as stress oxidants.
Methods: In a cross-sectional study, 220 people were studied. After physical
examination and blood sampling, they were interviewed by a psychiatrist based on
diagnostic and statistical manual of mental disease (DSM IV) for ruling out mental
disorders. Standard questionnaire of memory deficit were filled out. Based on this
questionnaire population was classified into two groups: with memory deficit and
without memory deficit. Data was analysed based on t-test and by SPSS software.
P<0.05 was considered as a significant level.
Results: In our sample, mean age was 72.7±2.8. Mean level of malondialdhyde
(μmol/l) was 2.7±0.36 and 1.5±0.48, respectively in the presence and absence of
memory deficit (P<0.001). Mean antioxidant capacity was 74.5%±1.6 and
77.6%±1.36, respectively in persons with memory deficit and those without it
(P<0.0001). Glotation peroxidize (IU/g Hb) level was 35.1±1.8 and 37.21±1.6,
respectively in the presence and absence of memory deficit (P<0.0001).
Conclusion: Findings of this study suggest the theory of relation between high
stress oxidant and low antioxidant capacity with memory deficit. It seems that
treatment removing free radicals and stress oxidants can control the trend of
memory deficit.

Keywords

Memory – Memory Disorders – Oxidants – Aged

© 2007, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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